PMID- 8261135
OWN - NLM
STAT- MEDLINE
DCOM- 19940127
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 5
IP  - 6
DP  - 1993 Jun 1
TI  - Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat 
      brain and peripheral tissues.
PG  - 605-13
AB  - The neurotrophin gene family includes four structurally related proteins with 
      neurotrophic activities. Two of them, nerve growth factor and brain-derived 
      neurotrophic factor (BDNF), have been studied in detail and information has 
      recently emerged on the expression and function of the third member, 
      neurotrophin-3. In contrast, little information is available on neurotrophin-4 
      (NT-4), the most recently isolated member of this family. In this report we have 
      used a sensitive RNAase protection assay to analyse the developmental expression 
      of NT-4 mRNA in the rat brain and in 12 different rat peripheral organs. In 
      heart, liver and muscle plus skin NT-4 mRNA levels were maximal at embryonic day 
      (E) E13 (the earliest time point tested), with reduced levels at later times of 
      development. In lung, kidney and thymus similar levels were seen from E13 to 
      postnatal day (P) 1, with reduced levels in the adult. In testis, ovary and 
      salivary gland NT-4 mRNA was detected at E16 with a peak shortly after birth. 
      During brain development, NT-4 mRNA was maximal at E13 followed by a decrease 
      around birth, after which the level increased. The postnatal increase of NT-4 
      mRNA was also seen in cerebral cortex and brain stem analysed separately, while 
      in the hippocampus similar levels were found from P1 to adulthood. NT-4 mRNA was 
      detected in all ten adult rat brain regions analysed with only small regional 
      variations, being highest in pons-medulla, hypothalamus, thalamus and 
      cerebellum.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Timmusk, T
AU  - Timmusk T
AD  - Department of Medical Chemistry, Karolinska Institute, Stockholm, Sweden.
FAU - Belluardo, N
AU  - Belluardo N
FAU - Metsis, M
AU  - Metsis M
FAU - Persson, H
AU  - Persson H
LA  - eng
GR  - AG04418/AG/NIA NIH HHS/United States
GR  - NS09199/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Blotting, Northern
MH  - Brain/embryology/growth & development/*metabolism
MH  - Genitalia/metabolism
MH  - Nerve Growth Factors/*genetics
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tissue Distribution
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 10.1111/j.1460-9568.1993.tb00526.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 1993 Jun 1;5(6):605-13. doi: 10.1111/j.1460-9568.1993.tb00526.x.