PMID- 8264599
OWN - NLM
STAT- MEDLINE
DCOM- 19940121
LR  - 20210526
IS  - 0270-7306 (Print)
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Linking)
VI  - 14
IP  - 1
DP  - 1994 Jan
TI  - Nucleosome-mediated disruption of transcription factor-chromatin initiation 
      complexes at the mouse mammary tumor virus long terminal repeat in vivo.
PG  - 32-41
AB  - Glucocorticoid induction of mouse mammary tumor virus (MMTV) is short lived, 
      returning to base levels within 24 h despite the continued presence of hormone. 
      MMTV DNA sequences assembled as chromatin require hormone for binding by nuclear 
      factor 1 (NF1) and octamer proteins (OCT). However, in the same cells, NF1 and 
      OCT factors are bound to transiently introduced DNA in the absence of hormone. In 
      contrast, recruitment of the TATA-binding protein and a novel DNA-binding 
      protein, which we have designated FDT, for factor downstream of the TATA-binding 
      protein, is hormone dependent for both stable and transient templates. 
      Furthermore, transient DNA templates, but not nucleosomal templates, retain these 
      transcription factors over the course of 24 h. This finding suggests that MMTV 
      chromatin structure contributes to activation and cessation of transcription in 
      vivo.
FAU - Lee, H L
AU  - Lee HL
AD  - Department of Obstetrics & Gynecology, University of Western Ontario, London, 
      Canada.
FAU - Archer, T K
AU  - Archer TK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (CCAAT-Enhancer-Binding Proteins)
RN  - 0 (Chromatin)
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Viral)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NFI Transcription Factors)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nucleosomes)
RN  - 0 (RNA, Messenger)
RN  - 0 (TATA-Box Binding Protein)
RN  - 0 (Transcription Factors)
RN  - 0 (Y-Box-Binding Protein 1)
RN  - 0 (YBX1 protein, human)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - *CCAAT-Enhancer-Binding Proteins
MH  - Cell Line, Transformed
MH  - Chromatin/*metabolism
MH  - DNA Primers/genetics
MH  - DNA, Viral/genetics/metabolism
MH  - DNA-Binding Proteins/metabolism
MH  - Dexamethasone/pharmacology
MH  - Kinetics
MH  - Mammary Tumor Virus, Mouse/genetics/*metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - NFI Transcription Factors
MH  - Nuclear Proteins
MH  - Nucleosomes/*metabolism
MH  - Promoter Regions, Genetic/drug effects
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Repetitive Sequences, Nucleic Acid
MH  - TATA-Box Binding Protein
MH  - Transcription Factors/*metabolism
MH  - Transcription, Genetic
MH  - Y-Box-Binding Protein 1
PMC - PMC358353
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
PMCR- 1994/01/01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PHST- 1994/01/01 00:00 [pmc-release]
AID - 10.1128/mcb.14.1.32-41.1994 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1994 Jan;14(1):32-41. doi: 10.1128/mcb.14.1.32-41.1994.