PMID- 8264958
OWN - NLM
STAT- MEDLINE
DCOM- 19940125
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 159
IP  - 1-2
DP  - 1993 Sep 3
TI  - Ganglioside GM1 cooperates with brain-derived neurotrophic factor to protect 
      dopaminergic neurons from 6-hydroxydopamine-induced degeneration.
PG  - 147-50
AB  - Brain-derived neurotrophic factor (BDNF) has recently been shown to enhance the 
      survival of dopaminergic neurons in cultures derived from the embryonic rat 
      mesencephalon. In the present study BDNF was found to protect cultured 
      dopaminergic neurons from injury induced by acute exposure to the 
      dopaminergic-selective neurotoxin 6-hydroxydopamine. The BDNF effect was 
      concentration (ED50 approximately 10 ng/ml) and time-dependent, as determined by 
      tyrosine hydroxylase immunocytochemistry. More importantly, subthreshold amounts 
      of BDNF were rendered efficacious in the presence of ganglioside GM1: loss of 
      tyrosine hydroxylase positive cells was reduced from 80% to only 20%. Thus GM1 
      may provide a fruitful treatment strategy for disorders of dopamine function such 
      as Parkinson's disease.
FAU - Fadda, E
AU  - Fadda E
AD  - Fidia Research Laboratories, Abano Terme, Italy.
FAU - Negro, A
AU  - Negro A
FAU - Facci, L
AU  - Facci L
FAU - Skaper, S D
AU  - Skaper SD
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 37758-47-7 (G(M1) Ganglioside)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Cells, Cultured
MH  - Dopamine/*physiology
MH  - Female
MH  - G(M1) Ganglioside/*physiology
MH  - Nerve Degeneration/drug effects
MH  - Nerve Growth Factors/*physiology
MH  - Nerve Tissue Proteins/*physiology
MH  - Neurons/*drug effects
MH  - Oxidopamine/*antagonists & inhibitors/toxicity
MH  - Pregnancy
MH  - Rats
MH  - Recombinant Proteins/metabolism
EDAT- 1993/09/03 00:00
MHDA- 1993/09/03 00:01
CRDT- 1993/09/03 00:00
PHST- 1993/09/03 00:00 [pubmed]
PHST- 1993/09/03 00:01 [medline]
PHST- 1993/09/03 00:00 [entrez]
AID - 0304-3940(93)90820-B [pii]
AID - 10.1016/0304-3940(93)90820-b [doi]
PST - ppublish
SO  - Neurosci Lett. 1993 Sep 3;159(1-2):147-50. doi: 10.1016/0304-3940(93)90820-b.