PMID- 8265302
OWN - NLM
STAT- MEDLINE
DCOM- 19940125
LR  - 20100324
IS  - 0031-4005 (Print)
IS  - 0031-4005 (Linking)
VI  - 93
IP  - 1
DP  - 1994 Jan
TI  - Clinical features of infants with primary human herpesvirus 6 infection (exanthem 
      subitum, roseola infantum).
PG  - 104-8
AB  - OBJECTIVE: To clarify clinical features of patients with primary human 
      herpesvirus 6 (HHV-6) infection (roseola infantum, exanthem subitum) in a 
      large-scale study. SUBJECTS AND METHODS: Clinical signs and symptoms were 
      analyzed in 176 infants in whom exanthem subitum was initially suspected and 
      primary HHV-6 infection was later confirmed. The infection was proved by 
      isolation of the virus from blood, a significant increase in the neutralizing 
      antibody titers to the virus, or both. RESULTS: The primary HHV-6 infection, 
      which occurred throughout the year, was observed in 94 boys and 82 girls (mean 
      age, 7.3 months). Fever developed in 98% (mean maximum fever, 39.4 degrees C) and 
      lasted for 4.1 days. Macular or papular rashes appeared in 98%, on face, trunk, 
      or both, mostly at the time of subsidence of the fever, and lasted for 3.8 days. 
      Other clinical manifestations occurred as follows: mild diarrhea in 68%, 
      edematous eyelids in 30%, erythematous papules in the pharynx in 65%, cough in 
      50%, and mild cervical lymph node swelling in 31%. Twenty-six percent had bulging 
      of the anterior fontanelle and 8% had convulsions. CONCLUSIONS: Clinical features 
      of patients with virologically confirmed exanthem subitum were comparable with 
      those described before discovery of HHV-6.
FAU - Asano, Y
AU  - Asano Y
AD  - Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, 
      Japan.
FAU - Yoshikawa, T
AU  - Yoshikawa T
FAU - Suga, S
AU  - Suga S
FAU - Kobayashi, I
AU  - Kobayashi I
FAU - Nakashima, T
AU  - Nakashima T
FAU - Yazaki, T
AU  - Yazaki T
FAU - Kajita, Y
AU  - Kajita Y
FAU - Ozaki, T
AU  - Ozaki T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Exanthema Subitum/*diagnosis/microbiology
MH  - Female
MH  - Herpesviridae Infections/*diagnosis
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Pediatrics. 1994 Jan;93(1):104-8.