PMID- 8265771
OWN - NLM
STAT- MEDLINE
DCOM- 19940127
LR  - 20041117
IS  - 0033-5622 (Print)
IS  - 0033-5622 (Linking)
VI  - 86
IP  - 11
DP  - 1993 Nov
TI  - The role of skin biopsies in bone marrow transplant recipients.
PG  - 715-7
AB  - Bone marrow transplant (BMT) recipients frequently develop rashes as a 
      consequence of their disease, its treatment or because of a complication such as 
      infection. These rashes are often clinically atypical, yet appropriate management 
      is dependent upon correct diagnosis and therefore a skin biopsy is often 
      performed. In a group of 101 consecutive BMT recipients, 25 patients had a total 
      of 34 skin biopsies. A specific histopathological diagnosis was made in 65% 
      (22/34), including graft vs. host disease (GVHD) (15 cases), infection (4 cases), 
      drug reaction (1 case) and recurrent lymphoma (1 case). Therapy was changed 
      following the biopsy in 77% (17/22) of these cases. In 35% (12/34) the 
      histological changes were non-specific, however, in 10 of these cases GVHD had 
      been suspected clinically and its exclusion was therefore useful. Skin biopsy is 
      of considerable value in the diagnosis and subsequent management of BMT 
      recipients who develop a rash.
FAU - Hepburn, N C
AU  - Hepburn NC
AD  - Department of Dermatology, Royal Infirmary, Edinburgh, UK.
FAU - McLaren, K M
AU  - McLaren KM
FAU - Turner, M L
AU  - Turner ML
FAU - Beveridge, G W
AU  - Beveridge GW
LA  - eng
PT  - Journal Article
PL  - England
TA  - Q J Med
JT  - The Quarterly journal of medicine
JID - 0401027
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Drug Hypersensitivity/pathology
MH  - Graft vs Host Disease/pathology
MH  - Humans
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Skin/*pathology
MH  - Skin Diseases/*pathology
MH  - Skin Diseases, Infectious/pathology
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
PST - ppublish
SO  - Q J Med. 1993 Nov;86(11):715-7.