PMID- 8268647
OWN - NLM
STAT- MEDLINE
DCOM- 19940131
LR  - 20131121
IS  - 1058-2916 (Print)
IS  - 1058-2916 (Linking)
VI  - 39
IP  - 3
DP  - 1993 Jul-Sep
TI  - Continuous venovenous hemodiafiltration compared with conventional dialysis in 
      critically ill patients with acute renal failure.
PG  - M794-7
AB  - The morbidity and mortality benefits of new forms of continuous renal replacement 
      therapy remain controversial. The authors have compared a cohort of consecutive 
      prospectively studied critically ill patients with acute renal failure treated 
      with continuous venovenous hemodiafiltration (CVVHD) (n = 76) to a previously 
      described antecedent group of patients treated in intensive care with 
      intermittent hemodialysis or peritoneal dialysis (conventional dialysis [CD]) (n 
      = 84). Patients were comparable for mean age, gender distribution, and mean 
      number of failing organs (CVVHD: 4; CD: 3.9). CVVHD patients were more severely 
      ill as measured by APACHE II score (CVVHD: score of 29; CD: score of 25.8). 
      Despite their greater illness severity, CVVHD patients more often survived to 
      hospital discharge (CVVHD: 40.8%) than did CD patients (CD: 29.8%; NS). After 
      adjustment for illness severity, in patients with two, three, or four failing 
      organs, survival was 54.3% for CVVHD versus 29.3% for CD (p < 0.01). Survival was 
      48% for CVVHD patients with an intermediate APACHE II score (24 to 29), compared 
      with 12.5% for comparable CD patients (p < 0.01). No statistically significant 
      differences were seen at either extreme of illness severity. Complications were 
      significantly fewer during CVVHD (1 vs. 18). These data support the view that 
      CVVHD reduces morbidity and mortality in critically ill patients with acute renal 
      failure.
FAU - Bellomo, R
AU  - Bellomo R
AD  - Intensive Care Unit, Monash Medical Centre, Clayton, Victoria, Australia.
FAU - Boyce, N
AU  - Boyce N
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Acute Kidney Injury/mortality/*therapy
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cholesterol/blood
MH  - *Critical Care
MH  - Female
MH  - Follow-Up Studies
MH  - Hemofiltration/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Renal Dialysis/*methods
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
PST - ppublish
SO  - ASAIO J. 1993 Jul-Sep;39(3):M794-7.