PMID- 8270767
OWN - NLM
STAT- MEDLINE
DCOM- 19940203
LR  - 20190512
IS  - 0022-1503 (Print)
IS  - 0022-1503 (Linking)
VI  - 84
IP  - 6
DP  - 1993 Nov-Dec
TI  - Inheritance of renal amyloidosis in Chinese Shar-pei dogs.
PG  - 438-42
AB  - Renal amyloidosis (RA) and recurrent fever of unknown origin (RFUO) are 
      characteristics of familial Mediterranean fever (FMF), a human disorder inherited 
      as an autosomal-recessive trait. Although no animal model has been established 
      for FMF, a similar syndrome of RFUO and RA has been reported in Chinese Shar-pei 
      (CSP) dogs. This report addresses two questions: (1) Is RA inherited in CSP dogs? 
      (2) If it is, is it possible to hypothesize the type of inheritance involved? Two 
      studies were conducted to answer these questions: a historical cross-sectional 
      comparison, which included CSP and non-CSP dogs with RA; and a prospective study 
      that included CSP dogs with RA, RFUO, or both. The cross-sectional comparison 
      resulted in an odds ratio of 10 for RA in CSP dogs under 7 years of age. The 
      prospective study of 28 dogs with RA or RFUO identified 20 that had RFUO and RA, 
      three with RA alone, and five with RFUO alone. RFUO preceded RA in all cases with 
      both conditions. The RFUO/RA combination was observed in both sexes. Four dogs 
      with RFUO with or without RA were born to parents that either were alive at age 7 
      or had died because of conditions other than kidney failure/RA. When one parent 
      was known to express one of these conditions, the prevalence of RA was between 
      25% and 50% among littermates.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Rivas, A L
AU  - Rivas AL
AD  - New York State College of Veterinary Medicine, Department of Pathology, Ithaca.
FAU - Tintle, L
AU  - Tintle L
FAU - Meyers-Wallen, V
AU  - Meyers-Wallen V
FAU - Scarlett, J M
AU  - Scarlett JM
FAU - van Tassell, C P
AU  - van Tassell CP
FAU - Quimby, F W
AU  - Quimby FW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Hered
JT  - The Journal of heredity
JID - 0375373
SB  - IM
MH  - Amyloidosis/complications/genetics/*veterinary
MH  - Animals
MH  - Cross-Sectional Studies
MH  - Disease Models, Animal
MH  - Dog Diseases/*genetics
MH  - Dogs
MH  - Female
MH  - Fever of Unknown Origin/complications/genetics/veterinary
MH  - Humans
MH  - Kidney Diseases/complications/genetics/*veterinary
MH  - Male
MH  - Pedigree
MH  - Prospective Studies
MH  - Recurrence
MH  - Species Specificity
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.jhered.a111369 [doi]
PST - ppublish
SO  - J Hered. 1993 Nov-Dec;84(6):438-42. doi: 10.1093/oxfordjournals.jhered.a111369.