PMID- 8273454
OWN - NLM
STAT- MEDLINE
DCOM- 19940201
LR  - 20171006
IS  - 0386-300X (Print)
IS  - 0386-300X (Linking)
VI  - 47
IP  - 5
DP  - 1993 Oct
TI  - Autoimmune responses as assessed by hypergammaglobulinemia and the presence of 
      autoantibodies in patients with chronic hepatitis C.
PG  - 305-10
AB  - We investigated autoimmunity, as assessed by hypergammaglobulinemia and the 
      presence of autoantibodies including anti-nuclear antibodies (ANA) and anti-liver 
      membrane antibodies (LMA), in 149 patients with chronic hepatitis C, 55 patients 
      with chronic hepatitis B and 11 patients with autoimmune hepatitis. There was no 
      significant difference in the incidence of these autoantibodies between chronic 
      hepatitis C and chronic hepatitis B. Nine patients with chronic hepatitis C 
      satisfied the serological criteria of autoimmune hepatitis (ANA positive and 
      gammaglobulin or serum IgG greater than 2500 mg/dl), but none of the patients 
      with chronic hepatitis B met the criteria. This suggests that autoimmunity is 
      greater in chronic hepatitis C than in chronic hepatitis B. Of the 9 patients 
      with chronic hepatitis C, all 4 patients tested for human leukocyte antigen (HLA) 
      phenotype had HLA-DR4, which is known to be associated with autoimmune hepatitis 
      in Japanese patients. We believe that hepatitis C virus (HCV) infection enhances 
      the initiation and perpetuation of autoimmunity in susceptible individuals.
FAU - Kawamoto, H
AU  - Kawamoto H
AD  - First Department of Internal Medicine, Okayama University Medical School, Japan.
FAU - Sakaguchi, K
AU  - Sakaguchi K
FAU - Takaki, A
AU  - Takaki A
FAU - Ogawa, S
AU  - Ogawa S
FAU - Tsuji, T
AU  - Tsuji T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Acta Med Okayama
JT  - Acta medica Okayama
JID - 0417611
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Antinuclear/analysis
MH  - Autoantibodies/*analysis
MH  - Autoimmune Diseases/immunology
MH  - *Autoimmunity
MH  - Chronic Disease
MH  - Female
MH  - Hepatitis/immunology
MH  - Hepatitis B/immunology
MH  - Hepatitis C/*complications/*immunology
MH  - Humans
MH  - Hypergammaglobulinemia/*etiology
MH  - Male
MH  - Middle Aged
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 10.18926/AMO/31582 [doi]
PST - ppublish
SO  - Acta Med Okayama. 1993 Oct;47(5):305-10. doi: 10.18926/AMO/31582.