PMID- 8275452
OWN - NLM
STAT- MEDLINE
DCOM- 19940204
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 71
IP  - 1
DP  - 1993 Nov
TI  - Tetrasomy 8 in acute monoblastic leukemia (AML-M5a) with myelosarcomatosis of the 
      skin.
PG  - 50-4
AB  - We report a new case with isolated tetrasomy 8, an 82-year-old female patient in 
      whom multiple disseminated nodular skin infiltrations up to 5 cm in diameter 
      preceded acute monoblastic leukemia (AML-M5a). Despite an initial response to 
      chemotherapy and radiotherapy, the patient died 1 year after diagnosis of 
      relapsed leukemia. To assess the size of the tetrasomic clone, fluorescence in 
      situ hybridization (FISH) analysis with a centromere-specific chromosome 8 probe 
      was performed. Seventy percent of interphase cells showed four signals and 22% 
      showed three signals. Because this trisomic clone was not detected by 
      conventional cytogenetics, tetrasomic cells may have a proliferation advantage in 
      vitro. Whether tetrasomy 8 arises from a simultaneous mitotic nondisjunction of 
      both chromosomes 8 during one cell division or evolves secondarily from trisomy 8 
      through a second mitotic error is not known. Alternatively, trisomy 8 may 
      originate from tetrasomy 8 by loss of one chromosome 8.
FAU - Marosi, C
AU  - Marosi C
AD  - Department of Internal Medicine I, University of Vienna, Austria.
FAU - Muhm, M
AU  - Muhm M
FAU - Argyriou-Tirita, A
AU  - Argyriou-Tirita A
FAU - Pehamberger, H
AU  - Pehamberger H
FAU - Pirc-Danoewinata, H
AU  - Pirc-Danoewinata H
FAU - Geissler, K
AU  - Geissler K
FAU - Locker, G
AU  - Locker G
FAU - Grois, N
AU  - Grois N
FAU - Haas, O A
AU  - Haas OA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Monocytic, Acute/*genetics/pathology
MH  - Leukemia, Myeloid/genetics/pathology
MH  - Leukemic Infiltration/*genetics/pathology
MH  - Skin/*pathology
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 0165-4608(93)90201-V [pii]
AID - 10.1016/0165-4608(93)90201-v [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1993 Nov;71(1):50-4. doi: 10.1016/0165-4608(93)90201-v.