PMID- 8275454
OWN - NLM
STAT- MEDLINE
DCOM- 19940204
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 71
IP  - 1
DP  - 1993 Nov
TI  - Partial trisomy of 3q detected by chromosome painting in a case of juvenile 
      chronic myelomonocytic leukemia.
PG  - 67-70
AB  - Juvenile chronic myelomonocytic leukemia (JCMMoL) is a rare disease with no 
      specific type of chromosome aberration yet delineated. We report a 2-year-old boy 
      who had in his leukemic bone marrow (BM) and peripheral blood (PB) cells the 
      46,XY,der(15)t(3;15)(q13.1;q26) karyotype. Phytohemagglutinin (PHA)-stimulated 
      lymphocytes of peripheral blood had a normal 46,XY karyotype. The origin of the 
      duplicated part of 3q was proved by fluorescence in situ hybridization (FISH) 
      with the pHSR(sat III 15p) DNA probe and a chromosome 3-specific DNA library 
      (i.e., chromosome painting). The chromosome finding in our case provides further 
      proof of the close relationship between the rearrangement in region 3q13-->3q26 
      and the pathogenesis of acute myeloid leukemia (AML). Our patient has transformed 
      into erythroleukemia [M6 according to the French-American-British (FAB) 
      classification] during the course of the disease.
FAU - Michalova, K
AU  - Michalova K
AD  - 3rd Medical Department, 1st Medical Faculty, Charles University, Prague, Czech 
      Republic.
FAU - Bartsch, O
AU  - Bartsch O
FAU - Stary, J
AU  - Stary J
FAU - Jelinek, J
AU  - Jelinek J
FAU - Wiegant, J
AU  - Wiegant J
FAU - Bubanska, E
AU  - Bubanska E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Cytokines)
SB  - IM
MH  - Cell Division/physiology
MH  - Cells, Cultured
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 3
MH  - Colony-Forming Units Assay
MH  - Cytokines/physiology
MH  - Hematopoietic Stem Cells/cytology
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Myelomonocytic, Chronic/*genetics/pathology
MH  - Male
MH  - *Trisomy
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 0165-4608(93)90203-X [pii]
AID - 10.1016/0165-4608(93)90203-x [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1993 Nov;71(1):67-70. doi: 10.1016/0165-4608(93)90203-x.