PMID- 8275460 OWN - NLM STAT- MEDLINE DCOM- 19940204 LR - 20190816 IS - 0165-4608 (Print) IS - 0165-4608 (Linking) VI - 71 IP - 1 DP - 1993 Nov TI - Concordance between karyotyping and in situ hybridization procedures in the detection of monosomy 9 in bladder cancer. PG - 97-9 AB - Twenty-three cases of transitional cell carcinoma (TCC) with a diploid model chromosome count as selected after karyotyping were analyzed by fluorescence in situ hybridization (FISH), using a probe for the heterochromatic region of chromosome 9. A monosomy for chromosome 9 was detected in 50% by karyotyping and after FISH in 52% of the cases. A full concordance between FISH and conventional karyotyping was found. We concluded that FISH can be reliably applied to interphase nuclei of TCC for the detection of numerical chromosome 9 aberrations. FAU - Smeets, W AU - Smeets W AD - Hospital Pharmacy and Laboratory for Clinical Chemistry, Venray, The Netherlands. FAU - Schapers, R AU - Schapers R FAU - Hopman, A AU - Hopman A FAU - Pauwels, R AU - Pauwels R FAU - Ramaekers, F AU - Ramaekers F LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - Cancer Genet Cytogenet JT - Cancer genetics and cytogenetics JID - 7909240 SB - IM MH - Aged MH - Aged, 80 and over MH - Carcinoma, Transitional Cell/*genetics MH - *Chromosomes, Human, Pair 9 MH - Female MH - Humans MH - *In Situ Hybridization, Fluorescence MH - *Karyotyping MH - Male MH - Middle Aged MH - *Monosomy MH - Urinary Bladder Neoplasms/*genetics EDAT- 1993/11/01 00:00 MHDA- 1993/11/01 00:01 CRDT- 1993/11/01 00:00 PHST- 1993/11/01 00:00 [pubmed] PHST- 1993/11/01 00:01 [medline] PHST- 1993/11/01 00:00 [entrez] AID - 0165-4608(93)90208-4 [pii] AID - 10.1016/0165-4608(93)90208-4 [doi] PST - ppublish SO - Cancer Genet Cytogenet. 1993 Nov;71(1):97-9. doi: 10.1016/0165-4608(93)90208-4.