PMID- 8276543
OWN - NLM
STAT- MEDLINE
DCOM- 19940208
LR  - 20091111
IS  - 0020-8868 (Print)
IS  - 0020-8868 (Linking)
VI  - 78
IP  - 3
DP  - 1993 Jul-Sep
TI  - Results of surgical resection of stage IIIa (N2) non small cell lung cancer, 
      according to the site of the mediastinal metastases.
PG  - 213-7
AB  - Out of a series of 1563 consecutive patients submitted to thoracotomy for lung 
      cancer between 1980 and 1990, 278 patients underwent a resection for a non small 
      cell lung cancer (NSCLC) with mediastinal node metastases (N2). Selection of 
      cases for surgery was carried out using CT from 1983 and mediastinoscopy for the 
      patients with mediastinal lymph nodes larger than 1.5 cm from 1985: all patients 
      with positive mediastinoscopy were excluded from thoracotomy, but 10 cases 
      underwent a resection after neoadjuvant radio-chemotherapy. The surgical 
      procedures were pneumonectomy (106), lobectomy (146) and atypical resection (8) 
      with ipsilateral mediastinal lymphadenectomy. Resection was complete in 236 
      patients (84.8%) and incomplete in 42 patients (15.2%). Postoperative mortality 
      was 3.2%. Almost all patients received radiotherapy after surgery. Actuarial 
      5-year survival was 13.7% for the entire group and 18.5% for the patients who 
      underwent curative resection; no patients survived 5 years after palliative 
      resection (p < 0.05). There were no differences with regard to prognosis 
      according to the histology of the tumors and to surgical procedures. A better 
      prognosis is associated with: completeness of resection, involvement of only one 
      level, low T classification. Five-year survival rate of patients with metastases 
      only in upper mediastinum was 25%; on the contrary 5-year survival rate of 
      patients with metastases in the lymph nodes of the lower mediastinum was only 8% 
      (p < 0.05). In our opinion better results among the patients with metastases in 
      the upper mediastinum depends on the selection obtained with 
      mediastinoscopy.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Maggi, G
AU  - Maggi G
AD  - Departement of Thoracic Surgery, University of Turin, Italy.
FAU - Casadio, C
AU  - Casadio C
FAU - Cianci, R
AU  - Cianci R
FAU - Molinatti, M
AU  - Molinatti M
FAU - Filosso, P L
AU  - Filosso PL
FAU - Nicolosi, M
AU  - Nicolosi M
FAU - Oliaro, A
AU  - Oliaro A
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Int Surg
JT  - International surgery
JID - 0043524
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/mortality/pathology/*secondary/*surgery
MH  - Humans
MH  - Lung Neoplasms/mortality/pathology/*surgery
MH  - Lymph Node Excision
MH  - Lymphatic Metastasis
MH  - Mediastinal Neoplasms/mortality/*secondary/*surgery
MH  - Neoplasm Staging
MH  - Pneumonectomy
MH  - Postoperative Complications/drug therapy/*mortality/radiotherapy
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Thoracotomy
MH  - Time Factors
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
PST - ppublish
SO  - Int Surg. 1993 Jul-Sep;78(3):213-7.