PMID- 8278020
OWN - NLM
STAT- MEDLINE
DCOM- 19940207
LR  - 20190920
IS  - 0305-1846 (Print)
IS  - 0305-1846 (Linking)
VI  - 19
IP  - 5
DP  - 1993 Oct
TI  - Selective excitotoxic pathology in the rat hippocampus.
PG  - 381-9
AB  - The pattern of cell loss and neuronal degeneration resulting from multiple 
      microinjections of N-methyl-D-aspartate (NMDA), ibotenate (IBO), quisqualate 
      (QUIS), and kainate (KA) into hippocampus was studied, together with the 
      protection provided by the NMDA antagonist 
      3-(+/-)-2-carboxypiperazin-4-yl-propyl-1-phosphonate (CPP). Histological 
      evaluation was carried out after 7 days of survival. NMDA and IBO resulted in an 
      extensive loss of all cells in the hippocampus including dentate gyrus, hilar 
      cells, and CA3-CA1 pyramidal cells, but there was an absence of damage to areas 
      and structures outside hippocampus. After QUIS and KA injections the hippocampal 
      damage was limited to hilar cells in the dentate gyrus, CA3 pyramidal cells, and 
      partial loss of CA1 cells; there was extensive extrahippocampal damage including 
      entorhinal cortex, amygdala, layers III, V, and VI of ventral neocortex, 
      olfactory areas, and various thalamic nuclei. CPP provided almost complete 
      protection from the effects of intrahippocampal injections of NMDA and IBO, but 
      did not affect the hippocampal cell loss found after QUIS and KA (with the 
      exception of minor protection of some CA1 cells). CPP protected most 
      extrahippocampal sites from the damage resulting from QUIS and KA, indicating 
      that such excitotoxic cell death is indirect and involves NMDA receptor 
      activation by an endogenous agent. The use of multiple microinjections as opposed 
      to single injections allows a clearer interpretation of selective excitotoxic 
      vulnerability.
FAU - Jarrard, L E
AU  - Jarrard LE
AD  - Washington and Lee University, Lexington, Virginia.
FAU - Meldrum, B S
AU  - Meldrum BS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropathol Appl Neurobiol
JT  - Neuropathology and applied neurobiology
JID - 7609829
RN  - 0 (Neurotoxins)
RN  - 0 (Piperazines)
RN  - 2552-55-8 (Ibotenic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - 98Y1I8ZD4M (3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/pathology
MH  - Brain Damage, Chronic/*chemically induced/pathology
MH  - Cell Death
MH  - Hippocampus/*drug effects/pathology
MH  - Ibotenic Acid/toxicity
MH  - Kainic Acid/toxicity
MH  - Male
MH  - N-Methylaspartate/toxicity
MH  - Nerve Degeneration
MH  - Neurotoxins/antagonists & inhibitors/*toxicity
MH  - Organ Specificity
MH  - Piperazines/pharmacology
MH  - Quisqualic Acid/toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 10.1111/j.1365-2990.1993.tb00458.x [doi]
PST - ppublish
SO  - Neuropathol Appl Neurobiol. 1993 Oct;19(5):381-9. doi: 
      10.1111/j.1365-2990.1993.tb00458.x.