PMID- 8279484
OWN - NLM
STAT- MEDLINE
DCOM- 19940204
LR  - 20121115
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 47
IP  - 6
DP  - 1993 Nov 1
TI  - Pathogenesis of craniofacial and body wall malformations induced by ochratoxin A 
      in mice.
PG  - 862-71
AB  - Ochratoxin A (OA), a mycotoxin commonly found in soils and on moldy food such as 
      cereal grains, is a potent teratogen. The present investigation was designed to 
      examine the teratogenicity of OA administered acutely at early post-implantation 
      stages in mice, with particular emphasis on the pathogenetic basis of induced 
      malformations. Maternal OA administration on gestational day (GD) 7 or 8 resulted 
      in excessive amounts of cell death in selected cell populations. After a single 
      dose of 2-4 mg/kg, excessive cell death was notable within 6 hours, and persisted 
      to 36 hours post-treatment. As observed in GD 14 or 18 fetuses, the spectrum of 
      induced craniofacial malformations included exencephaly, midfacial clefting, 
      cleft lip, as well as hypotelorism, and synophthalmia associated with 
      holoprosencephaly. Body wall defects involved either the abdominal wall alone, or 
      in combination with the thoracic wall, resulting in partial or complete exposure 
      of the viscera. Potential mechanisms for OA-induced selective cell killing are 
      discussed.
FAU - Wei, X
AU  - Wei X
AD  - University of North Carolina Birth Defects Center, Chapel Hill 27599-7090.
FAU - Sulik, K K
AU  - Sulik KK
LA  - eng
GR  - AA08204/AA/NIAAA NIH HHS/United States
GR  - HD28860/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - 0 (Ochratoxins)
RN  - 1779SX6LUY (ochratoxin A)
SB  - IM
MH  - Abnormalities, Drug-Induced/*pathology
MH  - Animals
MH  - Embryo, Mammalian/pathology/ultrastructure
MH  - Embryonic and Fetal Development
MH  - Facial Bones/*abnormalities/embryology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microscopy, Electron, Scanning
MH  - Muscles/*abnormalities/embryology
MH  - Ochratoxins/*toxicity
MH  - Skull/*abnormalities/embryology
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 10.1002/ajmg.1320470613 [doi]
PST - ppublish
SO  - Am J Med Genet. 1993 Nov 1;47(6):862-71. doi: 10.1002/ajmg.1320470613.