PMID- 8280124
OWN - NLM
STAT- MEDLINE
DCOM- 19940210
LR  - 20131121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 197
IP  - 3
DP  - 1993 Dec 30
TI  - Elevation of serum albumin by intrahepatic transplantation of albumin-producing 
      cells does not correct quantitative abnormalities of non-albumin proteins in 
      analbuminemic rats.
PG  - 1103-10
AB  - Nagase analbuminemic rats (NAR) show quantitative abnormalities of non-albumin 
      serum proteins which could represent a compensatory response to the 
      analbuminemia, although total serum protein levels are normal. When hyperplastic 
      hepatic nodule (HPN) cells of F344 rats, which produce albumin, were infused into 
      the portal vein of congenic analbuminemic rats (F344-alb) followed by treatment 
      with the Solt and Farber dietary regimen, the transplanted cells grew within the 
      livers, occasionally developing into hepatocellular carcinomas (HCC). In the 
      recipient F344-alb, while serum albumin was considerably elevated, the total 
      serum protein was also increased. Moreover, the abnormal pattern of serum 
      proteins in NAR was unchanged by the elevation of albumin. These results indicate 
      that the unique pattern of serum proteins in NAR is constitutive and cannot be 
      corrected by a continuous increase in albumin levels.
FAU - Ohta, T
AU  - Ohta T
AD  - Department of Pathology, Asahikawa Medical College, Japan.
FAU - Ogawa, K
AU  - Ogawa K
FAU - Nagase, S
AU  - Nagase S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Blood Proteins)
RN  - 0 (Serum Albumin)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Blood Proteins/isolation & purification/*metabolism
MH  - Cholesterol/blood
MH  - Hyperplasia
MH  - Liver/*metabolism/pathology
MH  - Liver Transplantation/*physiology
MH  - Male
MH  - Rats
MH  - Rats, Inbred F344
MH  - Rats, Mutant Strains
MH  - Serum Albumin/*biosynthesis/*deficiency/metabolism
MH  - Triglycerides/blood
EDAT- 1993/12/30 00:00
MHDA- 1993/12/30 00:01
CRDT- 1993/12/30 00:00
PHST- 1993/12/30 00:00 [pubmed]
PHST- 1993/12/30 00:01 [medline]
PHST- 1993/12/30 00:00 [entrez]
AID - S0006-291X(83)72591-X [pii]
AID - 10.1006/bbrc.1993.2591 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1993 Dec 30;197(3):1103-10. doi: 
      10.1006/bbrc.1993.2591.