PMID- 8281151
OWN - NLM
STAT- MEDLINE
DCOM- 19940217
LR  - 20190512
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 2
IP  - 11
DP  - 1993 Nov
TI  - A housekeeping type promoter, located in the 3' region of the Duchenne muscular 
      dystrophy gene, controls the expression of Dp71, a major product of the gene.
PG  - 1883-8
AB  - The 70.8 kDa protein product of the distal part of the giant Duchenne muscular 
      dystrophy (DMD) gene, Dp71, is expressed in many cell types and tissues. Anchored 
      PCR, primer extension and functional analysis of transfected constructs were used 
      to determine the 5' end of the mRNA and characterize the promoter of this major 
      DMD gene product. The 5' untranslated region (5'UTR) of Dp71 is transcribed from 
      a single exon; the promoter does not contain a TATA box, and has a very high GC 
      content and several potential Sp1 binding sites. It is located more than 2000 kb 
      3' to the muscle and brain type dystrophin promoters and only 150 kb from the 3' 
      end of the gene, suggesting that in most DMD patients the expression of Dp71 is 
      unaffected.
FAU - Lederfein, D
AU  - Lederfein D
AD  - Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
FAU - Yaffe, D
AU  - Yaffe D
FAU - Nudel, U
AU  - Nudel U
LA  - eng
SI  - GENBANK/U00789
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Dystrophin)
RN  - 0 (RNA, Messenger)
RN  - 0 (apo-dystrophin 1)
RN  - EC 2.3.1.28 (Chloramphenicol O-Acetyltransferase)
SB  - IM
GS  - DMD
MH  - Animals
MH  - Base Composition
MH  - Base Sequence
MH  - Brain/metabolism
MH  - Carcinoma, Hepatocellular
MH  - Chloramphenicol O-Acetyltransferase/metabolism
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Dystrophin/*analogs & derivatives/genetics
MH  - Exons
MH  - Humans
MH  - Liver Neoplasms
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muscles/metabolism
MH  - Muscular Dystrophy, Animal/*genetics
MH  - Neuroblastoma
MH  - Polymerase Chain Reaction
MH  - *Promoter Regions, Genetic
MH  - RNA, Messenger/biosynthesis/metabolism
MH  - Repetitive Sequences, Nucleic Acid
MH  - Restriction Mapping
MH  - Sequence Homology, Nucleic Acid
MH  - Transcription, Genetic
MH  - Transfection
MH  - Tumor Cells, Cultured
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 10.1093/hmg/2.11.1883 [doi]
PST - ppublish
SO  - Hum Mol Genet. 1993 Nov;2(11):1883-8. doi: 10.1093/hmg/2.11.1883.