PMID- 8281428
OWN - NLM
STAT- MEDLINE
DCOM- 19940214
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 626
IP  - 1-2
DP  - 1993 Oct 29
TI  - Desmethylimipramine, a potent inhibitor of synaptosomal norepinephrine uptake, 
      has diverse effects on thyroid hormone processing in rat brain. I. Effects on in 
      vivo uptake of 125I-labeled thyroid hormones in rat brain.
PG  - 175-83
AB  - Several lines of evidence point to an interaction between amine uptake inhibitors 
      (tricyclic antidepressants) and thyroid hormones. To examine this issue under 
      conditions which would minimize secondary effects of drug treatment, 
      desmethylimipramine (DMI), a highly specific norepinephrine uptake inhibitor, was 
      given acutely as a single i.p. dose one hour before i.v. [125I]triiodothyronine 
      (T3*) or [125I]thyroxine (T4*). Tissues were analysed after rat decapitation at 
      3, 5, 10, and 20 min intervals thereafter. DMI had a small but significant 
      inhibitory effect on the brain uptake of both T3* (7.4%) and T4* (19%) over their 
      respective 20-min time courses as indicated by two-way ANOVA. To examine the drug 
      response further and to determine the effect of thyroid status on the response, 
      hypothyroid (HYPO) and T4-induced hyperthyroid (HYPER) rats, were given i.v. T3* 
      and, 5 min later, i.p. DMI or saline. They were killed 3 h later and tissue 
      analysed. Because DMI effects on T4* uptake could not be evaluated over a 3 h 
      period without blocking T4* to T3* conversion, sodium ipodate (60 mg/kg) was 
      given in 2 doses before i.v. T4*. Under these conditions, DMI significantly 
      reduced brain concentrations of the administered T3* and T4* in HYPO (15% and 
      19%) and in HYPER rats (13% and 25%). These results suggest that, as it does in 
      the case of norepinephrine, DMI blocks the uptake site for T3 and T4 in rat 
      brain. No information is available regarding the relationship, if any, between 
      the thyroid hormone and norepinephrine uptake sites.
FAU - Gordon, J T
AU  - Gordon JT
AD  - Department of Psychiatry, University of Pennsylvania, Philadelphia.
FAU - Martens, D A
AU  - Martens DA
FAU - Tomlinson, E E
AU  - Tomlinson EE
FAU - Greenberg, J
AU  - Greenberg J
FAU - Dratman, M B
AU  - Dratman MB
LA  - eng
GR  - MH44210/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Thyroid Hormones)
RN  - TG537D343B (Desipramine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Brain/blood supply/*drug effects/metabolism
MH  - Desipramine/*pharmacology
MH  - Hyperthyroidism/metabolism
MH  - Hypothyroidism/metabolism
MH  - Iodine Radioisotopes
MH  - Kinetics
MH  - Male
MH  - Norepinephrine/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synaptosomes/*metabolism
MH  - Thyroid Hormones/*metabolism
EDAT- 1993/10/29 00:00
MHDA- 1993/10/29 00:01
CRDT- 1993/10/29 00:00
PHST- 1993/10/29 00:00 [pubmed]
PHST- 1993/10/29 00:01 [medline]
PHST- 1993/10/29 00:00 [entrez]
AID - 0006-8993(93)90577-A [pii]
AID - 10.1016/0006-8993(93)90577-a [doi]
PST - ppublish
SO  - Brain Res. 1993 Oct 29;626(1-2):175-83. doi: 10.1016/0006-8993(93)90577-a.