PMID- 8281521
OWN - NLM
STAT- MEDLINE
DCOM- 19940215
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 71
IP  - 2
DP  - 1993 Dec
TI  - Identification of a yeast artificial chromosome that spans the human papillary 
      renal cell carcinoma-associated t(X;1) breakpoint in Xp11.2.
PG  - 164-9
AB  - Recently, a specific chromosome abnormality, t(X;1)(p11;q21), was described for a 
      subgroup of human papillary renal cell carcinomas. The translocation breakpoint 
      in Xp11 is located in the same region as that in t(X;18)(p11;q11)-positive 
      synovial sarcoma. We used fluorescence in situ hybridization (FISH) and somatic 
      cell hybridization techniques to demonstrate 1) that the Xp11 translocation 
      breakpoint in papillary renal cell carcinoma differs from that observed in 
      synovial sarcoma and has a more proximal location, and 2) that an ornithine 
      aminotransferase (OAT)L2 containing yeast artificial chromosome (YAC) spans the 
      X;1 translocation. This YAC provides an ideal starting point from which the 
      breakpoint itself and the gene(s) involved can be isolated and characterized.
FAU - Suijkerbuijk, R F
AU  - Suijkerbuijk RF
AD  - Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
FAU - Meloni, A M
AU  - Meloni AM
FAU - Sinke, R J
AU  - Sinke RJ
FAU - de Leeuw, B
AU  - de Leeuw B
FAU - Wilbrink, M
AU  - Wilbrink M
FAU - Janssen, H A
AU  - Janssen HA
FAU - Geraghty, M T
AU  - Geraghty MT
FAU - Monaco, A P
AU  - Monaco AP
FAU - Sandberg, A A
AU  - Sandberg AA
FAU - Geurts van Kessel, A
AU  - Geurts van Kessel A
LA  - eng
GR  - CA-41185/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.6.1.13 (Ornithine-Oxo-Acid Transaminase)
SB  - IM
GS  - OATL1
GS  - OATL2
MH  - Animals
MH  - Blotting, Southern
MH  - Carcinoma, Renal Cell/*genetics
MH  - Chromosome Mapping
MH  - *Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 1/*ultrastructure
MH  - Cloning, Molecular
MH  - Cricetinae
MH  - Cricetulus
MH  - Humans
MH  - Hybrid Cells
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Kidney Neoplasms/*genetics
MH  - Ornithine-Oxo-Acid Transaminase/genetics
MH  - Sarcoma, Synovial/genetics
MH  - *Translocation, Genetic
MH  - X Chromosome/*ultrastructure
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - 0165-4608(93)90024-G [pii]
AID - 10.1016/0165-4608(93)90024-g [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1993 Dec;71(2):164-9. doi: 10.1016/0165-4608(93)90024-g.