PMID- 8281978
OWN - NLM
STAT- MEDLINE
DCOM- 19940217
LR  - 20190825
IS  - 0014-2972 (Print)
IS  - 0014-2972 (Linking)
VI  - 23
IP  - 10
DP  - 1993 Oct
TI  - 11 beta-hydroxysteroid dehydrogenase isoforms and their implications for blood 
      pressure regulation.
PG  - 589-601
AB  - 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the reversible 
      conversion of physiological glucocorticoids (cortisol, corticosterone) to 
      inactive products. The enzyme thus protects non-selective renal mineralocorticoid 
      receptors from circulating glucocorticoids (ensuring aldosterone-selectivity in 
      vivo), excludes maternal glucocorticoids from the foetal circulation and 
      modulates glucocorticoid access to glucocorticoid receptors in other tissues. 11 
      beta-HSD has been purified from rat liver, antisera raised, a cDNA isolated and 
      its human homologue cloned. However, it is difficult to reconcile all of the 
      actions of 11 beta-HSD with a single enzyme. Here data are reviewed that 
      demonstrate not only molecular heterogeneity of the 'liver-type' 11 beta-HSD, but 
      also the existence of a novel high affinity isoform in the placenta and perhaps 
      distal nephron. These data are discussed in the light of their potential 
      physiological and pathological importance, with particular reference to the 
      pathogenesis of hypertension.
FAU - Seckl, J R
AU  - Seckl JR
AD  - University of Edinburgh, Department of Medicine, Western General Hospital, UK.
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
RN  - 0 (Isoenzymes)
RN  - 0 (Receptors, Steroid)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Animals
MH  - Blood Pressure/physiology
MH  - Gene Expression Regulation, Enzymologic/physiology
MH  - Humans
MH  - Hydroxysteroid Dehydrogenases/metabolism/*physiology
MH  - Isoenzymes/metabolism/*physiology
MH  - Models, Biological
MH  - Receptors, Steroid/*analysis
RF  - 138
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 10.1111/j.1365-2362.1993.tb00720.x [doi]
PST - ppublish
SO  - Eur J Clin Invest. 1993 Oct;23(10):589-601. doi: 
      10.1111/j.1365-2362.1993.tb00720.x.