PMID- 8283139
OWN - NLM
STAT- MEDLINE
DCOM- 19940216
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 55
IP  - 1
DP  - 1994 Jan
TI  - Hyperimmune serum modulates allergic response to spores in a murine model of 
      allergic aspergillosis.
PG  - 29-34
AB  - Allergic bronchopulmonary aspergillosis (ABPA) is a disease in atopic asthmatics 
      characterized by eosinophilia and elevated levels of immunoglobulin E (IgE) and 
      IgG antibodies to the ubiquitous fungus Aspergillus fumigatus (Af). The role of 
      specific antibodies in the disease process is not clear. In this study, BALB/c 
      mice were injected with hyperimmune serum from syngeneic mice exposed to soluble 
      antigen of Af. These mice were then exposed to either Af spores or soluble 
      antigen. Total IgE, Af-specific IgG1 (enzyme-linked immunosorbent assay) in 
      serum, and eosinophils (eosinophil peroxidase assay) in lungs and bone marrow 
      were measured. Histologic sections of lungs were examined for cellular 
      infiltration and morphologic changes. Results indicate a suppression of increase 
      in levels of antibodies and eosinophilia in mice receiving immune serum and 
      exposed to spores compared with controls receiving phosphate-buffered saline 
      treatment. Spores being the primary source of exposure to Af in ABPA, these 
      results are significant in understanding the role of preexisting specific 
      antibodies in patients.
FAU - Murali, P S
AU  - Murali PS
AD  - Department of Medicine and Pathology, Medical College of Wisconsin, Milwaukee.
FAU - Bamrah, B S
AU  - Bamrah BS
FAU - Choi, H
AU  - Choi H
FAU - Fink, J N
AU  - Fink JN
FAU - Kurup, V P
AU  - Kurup VP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Antibodies, Fungal)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 1.11.1.- (Eosinophil Peroxidase)
RN  - EC 1.11.1.- (Peroxidases)
SB  - IM
MH  - Animals
MH  - Antibodies, Fungal/immunology
MH  - Aspergillosis, Allergic Bronchopulmonary/etiology/*immunology/pathology
MH  - Aspergillus fumigatus/*immunology
MH  - Bone Marrow/pathology
MH  - Eosinophil Peroxidase
MH  - Eosinophilia/prevention & control
MH  - Female
MH  - *Immunization, Passive
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/immunology
MH  - Lung/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Peroxidases/metabolism
MH  - Spores, Fungal/*immunology
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1002/jlb.55.1.29 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1994 Jan;55(1):29-34. doi: 10.1002/jlb.55.1.29.