PMID- 8283249
OWN - NLM
STAT- MEDLINE
DCOM- 19940216
LR  - 20220223
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 14
IP  - 1
DP  - 1994 Jan
TI  - Different kinetics govern dopaminergic transmission in the amygdala, prefrontal 
      cortex, and striatum: an in vivo voltammetric study.
PG  - 442-50
AB  - The regulation of extracellular dopamine (DA) concentrations was examined and 
      compared in vivo in four projection fields of mesotelencephalic dopaminergic 
      neurons with fast-scan cyclic voltammetry at carbon-fiber microelectrodes. 
      Transient electrical stimulation of ascending DA fibers in a near physiological 
      range of frequencies (10-20 Hz) elicited similar levels of extracellular DA in 
      the medial prefrontal cortex (MPFC), basal lateral amygdaloid nucleus (BAN), 
      caudate-putamen (CP), and nucleus accumbens (NAc) despite the documented 90-fold 
      disparity in DA tissue levels and terminal density. However, marked differences 
      were observed in the dynamics and overall frequency dependence of the evoked 
      synaptic overflow of DA. These differences are due to the significantly different 
      rates of release and uptake found in each of the four regions. For example, rate 
      constants for the release of the four regions. For example, rate constants for 
      the release and uptake of DA were similar in the MPFC and BAN but approximately 8 
      and 50 times less, respectively, than that in the CP and NAc. When the parameters 
      were normalized to endogenous DA tissue content, a unique picture emerged: 
      compared to all other regions, relative release was 10-fold greater in the MPFC 
      while relative uptake was at least 10 times less in the BAN. The results further 
      differentiate the functional characteristics of mesotelencephalic dopaminergic 
      systems and demonstrate the regiospecific nature of DA neural transmission in the 
      brain. In addition, the regulation of extracellular DA levels in the MPFC and BAN 
      is suitable for the "long-range" transfer of chemical information in the brain 
      and is consistent with a hypothesis of extrasynaptic neurotransmission.
FAU - Garris, P A
AU  - Garris PA
AD  - Department of Chemistry, University of North Carolina at Chapel Hill 27599-3290.
FAU - Wightman, R M
AU  - Wightman RM
LA  - eng
GR  - NS15841/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Amygdala/*physiology
MH  - Animals
MH  - Corpus Striatum/*physiology
MH  - Dopamine/metabolism/*physiology
MH  - Electric Stimulation
MH  - Electrophysiology
MH  - Kinetics
MH  - Male
MH  - Medial Forebrain Bundle/physiology
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Synaptic Transmission
PMC - PMC6576851
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
PMCR- 1994/07/01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PHST- 1994/07/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.14-01-00442.1994 [doi]
PST - ppublish
SO  - J Neurosci. 1994 Jan;14(1):442-50. doi: 10.1523/JNEUROSCI.14-01-00442.1994.