PMID- 8287268
OWN - NLM
STAT- MEDLINE
DCOM- 19940223
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 629
IP  - 1
DP  - 1993 Nov 26
TI  - Aluminum decreases muscarinic, adrenergic, and metabotropic receptor-stimulated 
      phosphoinositide hydrolysis in hippocampal and cortical slices from rat brain.
PG  - 133-40
AB  - Effects of aluminum chloride (AlCl3) (0.1 to 1000 microM) on inositol phosphate 
      (IP) accumulation stimulated by carbachol (CARB), norepinephrine (NE) or 
      quisqualate (QUIS) were examined in rat hippocampal and cortical slices. In the 
      absence of agonist, only 1000 microM AlCl3 significantly reduced basal 
      accumulation of IPs. For CARB-stimulated IP accumulation, 100 microM and greater 
      AlCl3 significantly inhibited IP accumulation. In cortical slices, 1000 microM 
      AlCl3 reduced CARB-stimulated IP accumulation by 55% and in hippocampal slices 
      1000 microM AlCl3 inhibited IP accumulation by 40%. Similar effects of AlCl3 were 
      observed for NE-stimulated IP accumulation. In cortical slices, the 
      concentration-response for AlCl3 effects on agonist-stimulated IP accumulation 
      was significantly different from that in hippocampal slices. For QUIS-stimulated 
      accumulation of IPs, 1000 microM AlCl3 significantly inhibited IP accumulation in 
      hippocampal slices. However, in cortical slices a biphasic effect of AlCl3 was 
      observed. 500 and 1000 microM AlCl3 significantly inhibited IP accumulation, 
      whereas 10 and 50 microM AlCl3 significantly enhanced QUIS-stimulated IP 
      accumulation. In both hippocampal and cortical slices, 500 microM AlCl3 
      significantly inhibited CARB-, NE- or QUIS-stimulated IP accumulation at all 
      agonist concentrations (0.1 to 10000 microM) tested, indicating a post-receptor 
      effect on agonist-mediated IP accumulation. Stimulation of G-proteins with NaF 
      (5-30 mM) resulted in accumulation of IPs in hippocampal and cortical slices in 
      the absence of added agonists. NaF (5-30 mM) plus 1 mM CARB produced increased 
      accumulation of IPs over CARB or NaF alone.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Shafer, T J
AU  - Shafer TJ
AD  - Cellular and Molecular Toxicology Branch, United States Environmental Protection 
      Agency, Research Triangle Park, NC 27711.
FAU - Mundy, W R
AU  - Mundy WR
FAU - Tilson, H A
AU  - Tilson HA
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Aluminum Compounds)
RN  - 0 (Chlorides)
RN  - 0 (Inositol Phosphates)
RN  - 0 (Phosphatidylinositols)
RN  - 0 (Receptors, Adrenergic)
RN  - 0 (Receptors, Glutamate)
RN  - 0 (Receptors, Muscarinic)
RN  - 3CYT62D3GA (Aluminum Chloride)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - 8Y164V895Y (Carbachol)
RN  - 8ZYQ1474W7 (Sodium Fluoride)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Aluminum Chloride
MH  - Aluminum Compounds/*pharmacology
MH  - Animals
MH  - Carbachol/*pharmacology
MH  - Cerebral Cortex/drug effects/*metabolism
MH  - Chlorides/*pharmacology
MH  - Hippocampus/drug effects/*metabolism
MH  - Hydrolysis
MH  - In Vitro Techniques
MH  - Inositol Phosphates/*metabolism
MH  - Kinetics
MH  - Male
MH  - Norepinephrine/*pharmacology
MH  - Phosphatidylinositols/*metabolism
MH  - Quisqualic Acid/*pharmacology
MH  - Rats
MH  - Receptors, Adrenergic/drug effects/physiology
MH  - Receptors, Glutamate/drug effects/physiology
MH  - Receptors, Muscarinic/drug effects/physiology
MH  - Sodium Fluoride/pharmacology
EDAT- 1993/11/26 00:00
MHDA- 2000/06/01 09:00
CRDT- 1993/11/26 00:00
PHST- 1993/11/26 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1993/11/26 00:00 [entrez]
AID - 0006-8993(93)90491-5 [pii]
AID - 10.1016/0006-8993(93)90491-5 [doi]
PST - ppublish
SO  - Brain Res. 1993 Nov 26;629(1):133-40. doi: 10.1016/0006-8993(93)90491-5.