PMID- 8288635
OWN - NLM
STAT- MEDLINE
DCOM- 19940222
LR  - 20210210
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 269
IP  - 2
DP  - 1994 Jan 14
TI  - Brain-derived neurotrophic factor increases neurotrophin-3 expression in 
      cerebellar granule neurons.
PG  - 828-30
AB  - Neurotrophin-3 (NT-3) is a member of the neurotrophin gene family and is highly 
      expressed in the developing rat cerebellum. Here we show that brain-derived 
      neurotrophic factor (BDNF) increased by approximately 10-fold the NT-3 mRNA 
      levels in cultured cerebellar granule neurons isolated from postnatal rats, 
      whereas nerve growth factor (NGF) and NT-3 itself had no effect. The effect of 
      BDNF was additive to that of triiodothyronine (T3), which also increased NT-3 
      mRNA in these neurons. The drug K252a inhibited the BDNF-mediated stimulation of 
      NT-3 expression, suggesting an involvement of trkB receptors. Nuclear run-on 
      experiments showed that BDNF enhanced NT-3 transcription, whereas the stability 
      of NT-3 mRNA remained unchanged. The data presented are the first demonstration 
      that one neurotrophin regulates the expression of another and provide evidence 
      that NT-3 production in granule neurons is regulated by both BDNF and T3.
FAU - Leingartner, A
AU  - Leingartner A
AD  - Department of Neurochemistry, Max Planck Institute for Psychiatry, Martinsried, 
      Germany.
FAU - Heisenberg, C P
AU  - Heisenberg CP
FAU - Kolbeck, R
AU  - Kolbeck R
FAU - Thoenen, H
AU  - Thoenen H
FAU - Lindholm, D
AU  - Lindholm D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 06LU7C9H1V (Triiodothyronine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Cerebellum/*metabolism
MH  - Gene Expression/drug effects
MH  - In Vitro Techniques
MH  - Nerve Growth Factors/*metabolism
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Neurotrophin 3
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Transcription, Genetic/drug effects
MH  - Triiodothyronine/pharmacology
EDAT- 1994/01/14 00:00
MHDA- 1994/01/14 00:01
CRDT- 1994/01/14 00:00
PHST- 1994/01/14 00:00 [pubmed]
PHST- 1994/01/14 00:01 [medline]
PHST- 1994/01/14 00:00 [entrez]
AID - S0021-9258(17)42186-7 [pii]
PST - ppublish
SO  - J Biol Chem. 1994 Jan 14;269(2):828-30.