PMID- 8289093
OWN - NLM
STAT- MEDLINE
DCOM- 19940223
LR  - 20231120
IS  - 0167-594X (Print)
IS  - 0167-594X (Linking)
VI  - 16
IP  - 2
DP  - 1993 May
TI  - Loss in expression of the retinoblastoma gene product in human gliomas is 
      associated with advanced disease.
PG  - 159-65
AB  - The retinoblastoma susceptibility gene (RB), the prototype of the class of tumor 
      suppressor genes, is inactivated in a number of human malignancies. We 
      investigated a possible role of RB in human brain tumors. Immunoprecipitation 
      revealed frequent loss of RB protein expression in glioma cell lines (8/24), 
      which was accompanied by lack of RB encoded transcripts. Among seventeen primary 
      brain tumors studied by Western blotting, loss of Rb protein expression was 
      observed in WHO grade 3 and 4 gliomas (3/10). However, none of the low grade 
      gliomas and the other primary brain tumors investigated lacked RB protein 
      expression. These data suggest a role for RB in glial malignancy, and loss of Rb 
      expression appears to be associated with glial tumor progression.
FAU - Hamel, W
AU  - Hamel W
AD  - Department of Developmental Biology, Genentech, Inc., South San Francisco, 
      California.
FAU - Westphal, M
AU  - Westphal M
FAU - Shepard, H M
AU  - Shepard HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
RN  - 0 (Retinoblastoma Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/*metabolism
MH  - Child, Preschool
MH  - Female
MH  - Glioma/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retinoblastoma Protein/*biosynthesis
MH  - Tumor Cells, Cultured
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
AID - 10.1007/BF01324703 [doi]
PST - ppublish
SO  - J Neurooncol. 1993 May;16(2):159-65. doi: 10.1007/BF01324703.