PMID- 8290278
OWN - NLM
STAT- MEDLINE
DCOM- 19940224
LR  - 20071114
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 9
IP  - 2
DP  - 1994 Feb
TI  - Mapping of two genes encoding members of a distinct subfamily of MAX interacting 
      proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human 
      chromosome 10 and mouse chromosome 19.
PG  - 665-8
AB  - Both the MAD and the MXI1 genes encode basic-helix-loop-helix-leucine zipper 
      (bHLH-Zip) transcription factors which bind Max in vitro, forming a 
      sequence-specific DNA-binding complex similar to the Myc-Max heterodimer. Mad and 
      Myc compete for binding to Max. In addition, Mad has been shown to act as a 
      transcriptional repressor while Myc appears to function as an activator. Mxi1 
      also appears to lack a transcriptional activation domain. Therefore, Mxi1 and Mad 
      might antagonize Myc function and are candidate tumor suppressor genes. We report 
      here the mapping of the MAD and MXI1 genes in human and mouse by fluorescence in 
      situ hybridization (FISH) and by recombination mapping. The MAD gene was mapped 
      to human chromosome 2 at band p13 by FISH and to mouse chromosome 6 by meiotic 
      mapping. The MXI1 gene was mapped to human chromosome 10 at band q25 and on mouse 
      chromosome 19 at region D by FISH. There was a second site of hybridization on 
      mouse chromosome 2 at region C, which may represent a pseudogene or a related 
      sequence. The mapping results confirm regions of conservation between human 
      chromosome 2p13 and mouse chromosome 6 and between chromosome 10q25 and mouse 
      chromosome 19D. Human chromosomes 2p13 and 10q25 have been involved in specific 
      tumors where the role of Mad and Mxi1 can now be investigated.
FAU - Edelhoff, S
AU  - Edelhoff S
AD  - Department of Pathology, University of Washington, Seattle 98195.
FAU - Ayer, D E
AU  - Ayer DE
FAU - Zervos, A S
AU  - Zervos AS
FAU - Steingrimsson, E
AU  - Steingrimsson E
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Copeland, N G
AU  - Copeland NG
FAU - Eisenman, R N
AU  - Eisenman RN
FAU - Brent, R
AU  - Brent R
FAU - Disteche, C M
AU  - Disteche CM
LA  - eng
GR  - N01-CO-74101/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MAX protein, human)
RN  - 0 (Myc associated factor X)
RN  - 0 (Transcription Factors)
RN  - 137468-70-3 (Max protein, mouse)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - MAD
GS  - MAX
GS  - MXI1
MH  - Animals
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
MH  - Basic-Leucine Zipper Transcription Factors
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 10
MH  - *Chromosomes, Human, Pair 2
MH  - DNA/genetics
MH  - DNA-Binding Proteins/*genetics/physiology
MH  - Gene Expression Regulation/genetics
MH  - *Genes, Regulator
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leucine Zippers
MH  - Mice
MH  - Transcription Factors/*genetics/physiology
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
PST - ppublish
SO  - Oncogene. 1994 Feb;9(2):665-8.