PMID- 8294032
OWN - NLM
STAT- MEDLINE
DCOM- 19940301
LR  - 20220409
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 136
IP  - 1-2
DP  - 1993 Dec 22
TI  - A human gene that shows identity with the gene encoding the angiotensin receptor 
      is located on chromosome 11.
PG  - 355-60
AB  - We report the cloning of a gene, intronless in its coding region, which we have 
      named APJ. This gene was cloned using the polymerase chain reaction (PCR), with a 
      set of primers designed on the basis of the conservation that members of G 
      protein-coupled receptors (GPCR) have in their transmembrane (TM) regions. The 
      putative receptor protein, APJ, shares closest identity to the angiotensin 
      receptor (AT1) ranging from 40 to 50% in the hydrophobic TM regions of these 
      receptors. The transcripts for this gene were detected in many regions of the 
      brain. PCR analysis of somatic cell lines found APJ-related sequences to be only 
      present on chromosome 11, and high-resolution mapping by fluorescence in situ 
      hybridization (FISH) sublocalized APJ on band q12.
FAU - O'Dowd, B F
AU  - O'Dowd BF
AD  - Addiction Research Foundation, Toronto, Ontario, Canada.
FAU - Heiber, M
AU  - Heiber M
FAU - Chan, A
AU  - Chan A
FAU - Heng, H H
AU  - Heng HH
FAU - Tsui, L C
AU  - Tsui LC
FAU - Kennedy, J L
AU  - Kennedy JL
FAU - Shi, X
AU  - Shi X
FAU - Petronis, A
AU  - Petronis A
FAU - George, S R
AU  - George SR
FAU - Nguyen, T
AU  - Nguyen T
LA  - eng
SI  - GENBANK/D17345
SI  - GENBANK/D17346
SI  - GENBANK/D17347
SI  - GENBANK/D17348
SI  - GENBANK/D17349
SI  - GENBANK/L24529
SI  - GENBANK/U03642
SI  - GENBANK/X72989
SI  - GENBANK/Z15047
SI  - GENBANK/Z15048
GR  - NIDA 1 R01-DA07223-01/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Receptors, Angiotensin)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - APJ
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Cells, Cultured
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Cloning, Molecular
MH  - DNA
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - Receptors, Angiotensin/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
EDAT- 1993/12/22 00:00
MHDA- 1993/12/22 00:01
CRDT- 1993/12/22 00:00
PHST- 1993/12/22 00:00 [pubmed]
PHST- 1993/12/22 00:01 [medline]
PHST- 1993/12/22 00:00 [entrez]
AID - 0378-1119(93)90495-O [pii]
AID - 10.1016/0378-1119(93)90495-o [doi]
PST - ppublish
SO  - Gene. 1993 Dec 22;136(1-2):355-60. doi: 10.1016/0378-1119(93)90495-o.