PMID- 8294859
OWN - NLM
STAT- MEDLINE
DCOM- 19940303
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 179
IP  - 2
DP  - 1994 Feb 1
TI  - The mouse mammary tumor virus envelope gene product is required for superantigen 
      presentation to T cells.
PG  - 439-46
AB  - Transgenic mice expressing either the mouse mammary tumor virus (MMTV) 
      superantigen gene (sag) alone or in combination with the viral envelope genes 
      (env) (LEL), or all of the viral genes (gag, pol, env, and sag) (HYB PRO), 
      deleted V beta 14+ T cells from their immune repertoire. However, only LEL or HYB 
      PRO transgenic antigen-presenting cells were capable of stimulating a 
      proliferative response from nontransgenic primary T cells or interleukin 2 
      production from a V beta 15-bearing T cell hybridoma. These T cell responses 
      could be inhibited by a monospecific antibody directed against the MMTV gp52 cell 
      surface glycoprotein. These results indicate that the MMTV gp52 gene product 
      participates in the presentation of superantigen to T cells, resulting in their 
      stimulation, a requisite step in the MMTV infection pathway. Thus, gp52 could 
      play a role in the transfer of virus between different subsets of lymphocytes.
FAU - Golovkina, T V
AU  - Golovkina TV
AD  - Department of Biochemistry, University of Illinois College of Medicine, Chicago 
      60612.
FAU - Chervonsky, A
AU  - Chervonsky A
FAU - Prescott, J A
AU  - Prescott JA
FAU - Janeway, C A Jr
AU  - Janeway CA Jr
FAU - Ross, S R
AU  - Ross SR
LA  - eng
GR  - AI-14579/AI/NIAID NIH HHS/United States
GR  - CA-45954/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antigens, Viral)
RN  - 0 (Antigens, Viral, Tumor)
RN  - 0 (Superantigens)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (glycoprotein 52 antigen, Mouse mammary tumor virus)
SB  - IM
GS  - env
GS  - gag
GS  - pol
GS  - sag
MH  - Animals
MH  - Antigen-Presenting Cells/*physiology
MH  - Antigens, Viral/immunology
MH  - Antigens, Viral, Tumor/*genetics/immunology
MH  - Blotting, Western
MH  - Female
MH  - Male
MH  - Mammary Tumor Virus, Mouse/*immunology
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Superantigens/*immunology
MH  - T-Lymphocytes/*immunology
MH  - Viral Envelope Proteins/*genetics/immunology
PMC - PMC2191387
EDAT- 1994/02/01 00:00
MHDA- 2001/03/28 10:01
PMCR- 1994/08/01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
PHST- 1994/08/01 00:00 [pmc-release]
AID - 94125024 [pii]
AID - 10.1084/jem.179.2.439 [doi]
PST - ppublish
SO  - J Exp Med. 1994 Feb 1;179(2):439-46. doi: 10.1084/jem.179.2.439.