PMID- 8294882
OWN - NLM
STAT- MEDLINE
DCOM- 19940303
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 179
IP  - 2
DP  - 1994 Feb 1
TI  - Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) 
      on monocytes of atopic individuals.
PG  - 745-50
AB  - Suggestive evidence indicates that immunoglobulin E (IgE)-dependent activation of 
      mononuclear phagocytes plays an important pathogenic role in allergic tissue 
      inflammation. Prevailing opinion holds that low affinity IgE receptors are the 
      relevant IgE-binding structures on monocytes/macrophages and that functional 
      events occurring after cross-linking of membrane-bound IgE on these cells are 
      mediated by these receptors. Here we demonstrate that peripheral blood monocytes 
      can bind monomeric IgE via the high affinity IgE receptor (Fc epsilon RI) and 
      that Fc epsilon RI expression on these cells is upregulated in atopic persons. 
      Further, we demonstrate that, upon monocyte adherence to substrate, bridging of 
      monocyte Fc epsilon RI is followed by cell activation. We propose that direct 
      interaction of multivalent allergen with Fc epsilon RI(+)-bound IgE on 
      mononuclear phagocytes results in cell signaling via Fc epsilon RI and that the 
      biological consequences of this event may critically influence the outcome of 
      allergic reactions.
FAU - Maurer, D
AU  - Maurer D
AD  - Department of Dermatology, University of Vienna Medical School, Austria.
FAU - Fiebiger, E
AU  - Fiebiger E
FAU - Reininger, B
AU  - Reininger B
FAU - Wolff-Winiski, B
AU  - Wolff-Winiski B
FAU - Jouvin, M H
AU  - Jouvin MH
FAU - Kilgus, O
AU  - Kilgus O
FAU - Kinet, J P
AU  - Kinet JP
FAU - Stingl, G
AU  - Stingl G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Receptors, IgE)
SB  - IM
MH  - Animals
MH  - CHO Cells
MH  - Cell Line
MH  - Cricetinae
MH  - Flow Cytometry
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology
MH  - Monocytes/immunology/*metabolism
MH  - Receptors, IgE/*biosynthesis
PMC - PMC2191351
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
PMCR- 1994/08/01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
PHST- 1994/08/01 00:00 [pmc-release]
AID - 94125058 [pii]
AID - 10.1084/jem.179.2.745 [doi]
PST - ppublish
SO  - J Exp Med. 1994 Feb 1;179(2):745-50. doi: 10.1084/jem.179.2.745.