PMID- 8295481
OWN - NLM
STAT- MEDLINE
DCOM- 19940302
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 54
IP  - 6
DP  - 1994
TI  - 9-cis-retinoyl-beta-D-glucuronide is a major metabolite of 9-cis-retinoic acid.
PG  - PL69-74
AB  - The in vivo metabolism of 9-cis-retinoic acid (9-c-RA), an endogenous ligand of 
      retinoid X receptors (RXRs), which can also bind to retinoic acid receptors 
      (RARs), was examined in pregnant mice and rats following a single oral dose of 
      100 mg 9-cis-retinaldehyde (9-c-RAL)/kg body weight. 
      9-Cis-retinoyl-beta-D-glucuronide (9-c-RAG), a metabolite not found in vivo 
      before, was a major metabolite of 9-c-RA in mouse plasma and was also present in 
      all mouse tissues examined as well as in rat plasma. In both species putative 
      oxidation products of retinoic acids and high levels of retinyl esters were 
      found. Concentrations of retinoic acid isomers and retinoyl-beta-D-glucuronides 
      in the mouse plasma greatly exceeded those of the rat plasma. The finding of high 
      levels of 9-c-RAG underlines the importance of glucuronidation in the metabolism 
      of retinoids.
FAU - Sass, J O
AU  - Sass JO
AD  - Institut fur Toxikologie und Embryopharmakologie, Freie Universitat Berlin, 
      Germany.
FAU - Tzimas, G
AU  - Tzimas G
FAU - Nau, H
AU  - Nau H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 401-10-5 (retinoyl glucuronide)
RN  - 5688UTC01R (Tretinoin)
RN  - RR725D715M (Retinaldehyde)
SB  - IM
EIN - Life Sci 1994;54(17):PL311
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Embryo, Mammalian/metabolism
MH  - Female
MH  - Kidney/metabolism
MH  - Liver/metabolism
MH  - Mice
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Retinaldehyde/metabolism
MH  - Tretinoin/*analogs & derivatives/blood/*metabolism
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 0024-3205(94)00703-9 [pii]
AID - 10.1016/0024-3205(94)00703-9 [doi]
PST - ppublish
SO  - Life Sci. 1994;54(6):PL69-74. doi: 10.1016/0024-3205(94)00703-9.