PMID- 8300550
OWN - NLM
STAT- MEDLINE
DCOM- 19940308
LR  - 20191101
IS  - 0733-2459 (Print)
IS  - 0733-2459 (Linking)
VI  - 8
IP  - 3
DP  - 1993
TI  - Extracorporeal circuit heparinization in selective low density lipoprotein 
      apheresis: changes in patient hemostasis and low molecular weight heparin 
      benefit.
PG  - 141-6
AB  - Treatment by low density lipoprotein (LDL) apheresis using dextran sulfate 
      columns (DSC) leads to hemostasis alterations with prolonged activated partial 
      thromboplastin time (APTT) of more than 120 seconds. In order to explain this 
      hypocoagulability, we studied hemostasis parameters both in patients and in the 
      extracorporeal circulation (ECC). Hemostasis changes are first related to 
      unfractionated heparin (UFH)--needed to avoid circuit coagulation--which leads to 
      high residual heparinemia in the patient (more than 3 times the recommended level 
      for therapeutic use). Second, the hypocoagulability is induced by a coagulation 
      factor decrease (primarily factors V, VIII, and X) mainly due to an adsorption 
      mechanism on dextran sulfate. Studies on samples from column inflow, outflow, and 
      eluate confirm this mechanism. Low molecular weight heparin (LMWH) can be used in 
      LDL apheresis on DSC without major changes in lipid removal or coagulation 
      factors compared to UFH. The benefit of using LMWH is to reduce residual 
      heparinemia into the therapeutic range.
FAU - Lorenzini, J L
AU  - Lorenzini JL
AD  - Laboratoire d'Hematologie, CHU Hopital du Bocage, Universite de Bourgogne, Dijon, 
      France.
FAU - Dutrillaux, F
AU  - Dutrillaux F
FAU - Mousson, C
AU  - Mousson C
FAU - Lassale, B
AU  - Lassale B
FAU - Maynadie, M
AU  - Maynadie M
FAU - Rifle, G
AU  - Rifle G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Apher
JT  - Journal of clinical apheresis
JID - 8216305
RN  - 0 (Blood Coagulation Factors)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Nadroparin)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Adult
MH  - Blood Coagulation Factors/analysis
MH  - Blood Component Removal/instrumentation/*methods
MH  - Dextran Sulfate
MH  - *Extracorporeal Circulation
MH  - *Hemostasis
MH  - Humans
MH  - Hyperlipoproteinemia Type II/blood/*therapy
MH  - Lipoproteins, LDL/*blood
MH  - Middle Aged
MH  - *Nadroparin
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1002/jca.2920080302 [doi]
PST - ppublish
SO  - J Clin Apher. 1993;8(3):141-6. doi: 10.1002/jca.2920080302.