PMID- 8303087
OWN - NLM
STAT- MEDLINE
DCOM- 19940310
LR  - 20161123
IS  - 0034-5164 (Print)
IS  - 0034-5164 (Linking)
VI  - 82
IP  - 2
DP  - 1993 Nov
TI  - The inhibitory effects of salmon calcitonin on intrathecally-injected 
      N-methyl-D-aspartate-induced aversive behavior in mice.
PG  - 175-84
AB  - The effects of salmon calcitonin (SCT) on intrathecally-injected 
      N-methyl-D-aspartate (NMDA)-induced aversive behavior were investigated to 
      clarify the involvement of the NMDA receptor/ionophore complex on the analgesic 
      effects of SCT. Intracerebroventricular (i.c.v.) injection of SCT significantly 
      inhibited acetic acid-induced writhing. Intrathecal (i.t.) injection of NMDA 
      (0.25-1.0 nmol/mouse) dose-dependently induced aversive behavior such as 
      scratching and tail biting. SCT at the doses of 0.01 and 0.1 IU/mouse (i.c.v.) 
      significantly inhibited the NMDA-induced aversive behavior. This inhibitory 
      effects of SCT on NMDA (i.t.)-induced aversive behavior were neither potentiated 
      nor antagonized by i.c.v. injection of MK-801 and NMDA, respectively. Further, 
      MK-801 (i.c.v.) and NMDA (i.c.v.) themselves did not affect the NMDA 
      (i.t.)-induced aversive behavior. These results suggest that the NMDA 
      receptor/ionophore complex in the brain is not directly involved in the 
      antinociceptive effects of intracerebrally-injected SCT.
FAU - Nabeshima, T
AU  - Nabeshima T
AD  - Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University 
      School of Medicine, Japan.
FAU - Maeda, Y
AU  - Maeda Y
FAU - Yamada, K
AU  - Yamada K
FAU - Nakamura, T
AU  - Nakamura T
FAU - Hasegawa, T
AU  - Hasegawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Res Commun Chem Pathol Pharmacol
JT  - Research communications in chemical pathology and pharmacology
JID - 0244734
RN  - 0 (Analgesics)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 7SFC6U2VI5 (salmon calcitonin)
RN  - 9007-12-9 (Calcitonin)
SB  - IM
MH  - Analgesics/*pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain/drug effects
MH  - Calcitonin/*pharmacology
MH  - Injections, Intraventricular
MH  - Injections, Spinal
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - N-Methylaspartate/administration & dosage/*antagonists & inhibitors
MH  - Pain Measurement
MH  - Receptors, N-Methyl-D-Aspartate/drug effects/physiology
MH  - Salmon
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
PST - ppublish
SO  - Res Commun Chem Pathol Pharmacol. 1993 Nov;82(2):175-84.