PMID- 8305222
OWN - NLM
STAT- MEDLINE
DCOM- 19940314
LR  - 20190904
IS  - 0284-186X (Print)
IS  - 0284-186X (Linking)
VI  - 32
IP  - 7-8
DP  - 1993
TI  - A novel technetium-99m labeled monoclonal antibody (174H.64) for staging head and 
      neck cancer by immuno-SPECT.
PG  - 747-51
AB  - A novel murine monoclonal antibody (MAb 174H.64) was labeled with 99mTc by a 
      direct method. MAb 174H.64 detects a cytokeratin-associated antigen which is 
      expressed by over 90% of all squamous cell carcinomas. Panendoscopy, sonography 
      and computerized tomography scan were performed in all cases as well as magnetic 
      resonance imaging (in selected patients). Pre-operative immunoscintigraphy was 
      performed in 21 patients with histologically proven primary carcinomas (18 with 
      remaining primary tumors and 3 with lymph node recurrences). Scintigraphic images 
      were obtained 4-6 h after injection of 1.1 GBq of the 99mTc-labeled antibody (2 
      mg). Late images were acquired 18 to 24 h after injection. 
      Single-Photon-Emission-Computed Tomography (SPECT) of the head and thorax was 
      performed in all patients. The primary tumors were immunoscintigraphically 
      visualized in all 18 patients with remaining primary tumor. Fifteen of 18 
      loco-regional lymph node metastases were visualized by immunoscintigraphy (the 
      smallest lesions had a diameter of < 1 cm), in one patient lymph node metastases 
      were detected by immunoscan only. Two metastatically involved lymph nodes were 
      identified by histology only (micrometastases). Distant metastases were present 
      in 3 patients, of which two were identified by immunoscintigraphy. Immuno-SPECT 
      according to this method was a sensitive and specific imaging modality for 
      preoperative staging of patients with squamous cell carcinoma of the head and 
      neck and detected lymph node metastases with higher accuracy than conventional 
      clinical and imaging modalities.
FAU - Baum, R P
AU  - Baum RP
AD  - Department of Nuclear Medicine, Johann Wolfgang Goethe-University Medical Center, 
      Frankfurt/Main, Germany.
FAU - Adams, S
AU  - Adams S
FAU - Kiefer, J
AU  - Kiefer J
FAU - Niesen, A
AU  - Niesen A
FAU - Knecht, R
AU  - Knecht R
FAU - Howaldt, H P
AU  - Howaldt HP
FAU - Hertel, A
AU  - Hertel A
FAU - Adamietz, I A
AU  - Adamietz IA
FAU - Sykes, T
AU  - Sykes T
FAU - Boniface, G R
AU  - Boniface GR
AU  - et al.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Sweden
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
RN  - 0 (Antibodies, Monoclonal)
RN  - 7440-26-8 (Technetium)
SB  - IM
MH  - Animals
MH  - *Antibodies, Monoclonal
MH  - Carcinoma, Squamous Cell/diagnosis/*diagnostic imaging/pathology
MH  - Head and Neck Neoplasms/diagnosis/*diagnostic imaging/pathology
MH  - Humans
MH  - Lymphatic Metastasis/diagnosis/diagnostic imaging
MH  - Mice
MH  - Neoplasm Staging
MH  - Prospective Studies
MH  - Radioimmunodetection
MH  - *Technetium
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.3109/02841869309096131 [doi]
PST - ppublish
SO  - Acta Oncol. 1993;32(7-8):747-51. doi: 10.3109/02841869309096131.