PMID- 8305876
OWN - NLM
STAT- MEDLINE
DCOM- 19940317
LR  - 20191101
IS  - 0169-6009 (Print)
IS  - 0169-6009 (Linking)
VI  - 23
IP  - 2
DP  - 1993 Nov
TI  - Effect of transforming growth factor alpha, parathyroid hormone-related protein, 
      or their combination on bone histomorphometry.
PG  - 105-11
AB  - Transforming growth factor alpha (TGF alpha) has been implicated in the 
      pathogenesis of inhibited bone formation in hypercalcemia of malignancy. We 
      evaluated the effects of infusions of vehicle or TGF alpha (0.25 microgram/h), or 
      parathyroid hormone-related protein (1-34) (PTHrP) (0.025 microgram/h) alone, or 
      a combination of TGF alpha and PTHrP on bone histomorphometry in mice. The 
      peptides were infused for 6 days via Alzet osmotic minipumps. TGF alpha alone, 
      PTHrP alone, or a combination of the two resulted in an increase in bone 
      resorption as well as bone formation parameters. The increase in bone formation 
      with the combination of TGF alpha and PTHrP was significantly greater than that 
      seen with either peptide alone. Therefore, it is unlikely that TGF alpha is the 
      factor responsible for inhibited bone formation in hypercalcemia of malignancy.
FAU - Kukreja, S C
AU  - Kukreja SC
AD  - Endocrinology Section, VA West Side Medical Center, Chicago, IL 60612.
FAU - Rosol, T J
AU  - Rosol TJ
FAU - D'Anza, J J
AU  - D'Anza JJ
FAU - Wimbiscus, S A
AU  - Wimbiscus SA
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Bone Miner
JT  - Bone and mineral
JID - 8610542
RN  - 0 (Parathyroid Hormone-Related Protein)
RN  - 0 (Proteins)
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Animals
MH  - Bone Resorption
MH  - Bone and Bones/drug effects/*pathology
MH  - Drug Synergism
MH  - Infusion Pumps, Implantable
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Parathyroid Hormone-Related Protein
MH  - Proteins/administration & dosage/*pharmacology
MH  - Transforming Growth Factor alpha/administration & dosage/*pharmacology
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 10.1016/s0169-6009(08)80047-5 [doi]
PST - ppublish
SO  - Bone Miner. 1993 Nov;23(2):105-11. doi: 10.1016/s0169-6009(08)80047-5.