PMID- 8310449
OWN - NLM
STAT- MEDLINE
DCOM- 19940317
LR  - 20190821
IS  - 0041-0101 (Print)
IS  - 0041-0101 (Linking)
VI  - 31
IP  - 11
DP  - 1993 Nov
TI  - Distribution and elimination of ingested brevetoxin (PbTx-3) in rats.
PG  - 1483-6
AB  - As a first step towards understanding the pathologic effects of ingested 
      brevetoxin (PbTx) in marine mammals, we determined how [3H]PbTx-3 was distributed 
      and eliminated when ingested at sub-lethal dosages (18.6 micrograms/kg) by 
      Fischer 344 rats. Brevetoxin was distributed widely in the body, but concentrated 
      primarily in the liver. It was eliminated in equivalent quantities through the 
      urine and feces. However, we believe urinary clearance is the primary route for 
      PbTx-3 absorbed from the gastrointestinal tract.
FAU - Cattet, M
AU  - Cattet M
AD  - Department of Pathology, Ontario Veterinary College, University of Guelph, 
      Canada.
FAU - Geraci, J R
AU  - Geraci JR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Toxicon
JT  - Toxicon : official journal of the International Society on Toxinology
JID - 1307333
RN  - 0 (Marine Toxins)
RN  - 0 (Oxocins)
RN  - 98225-48-0 (brevetoxin)
SB  - IM
MH  - Animals
MH  - Male
MH  - Marine Toxins/*pharmacokinetics
MH  - *Oxocins
MH  - Rats
MH  - Rats, Inbred F344
MH  - Tissue Distribution
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 10.1016/0041-0101(93)90214-4 [doi]
PST - ppublish
SO  - Toxicon. 1993 Nov;31(11):1483-6. doi: 10.1016/0041-0101(93)90214-4.