PMID- 8311110
OWN - NLM
STAT- MEDLINE
DCOM- 19940317
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 144
IP  - 2
DP  - 1994 Feb
TI  - Expression of transforming growth factor-beta 1 and its relation to endomysial 
      fibrosis in progressive muscular dystrophy.
PG  - 221-6
AB  - Progressive muscular dystrophy is characterized by muscle fiber necrosis, 
      regeneration, and endomysial fibrosis. Although absence of dystrophin has been 
      known as the cause of muscle fiber degeneration, pathogenesis of interstitial 
      fibrosis is still unknown. Transforming growth factor-beta 1 (TGF-beta 1) induces 
      accumulation of extracellular matrix in various diseases, such as liver cirrhosis 
      and interstitial pneumonitis. To investigate its function on the pathogenesis of 
      progressive muscular dystrophy, it was necessary to determine the degree of 
      TGF-beta 1 expression and the site of TGF-beta 1 immunoreactivity. In Duchenne 
      muscular dystrophy and most of Becker muscular dystrophy, high TGF-beta 1 
      immunoreactivity expressed on muscle fibers and extracellular space. In other 
      myopathies with endomysial fibrosis, however, TGF-beta 1 was seldom observed. We 
      also examined the immunoreactivity of the latent TGF-beta binding protein, which 
      is bound to the TGF-beta precursors. In all Duchenne muscular dystrophy and half 
      of Becker muscular dystrophy cases, high latent TGF-beta 1 binding protein 
      immunoreactivity was seen, but in other myopathies its immunoreactivity was 
      seldom seen on muscle fibers or extracellular space. Therefore TGF-beta 1 may 
      play an important role in synthesis and accumulation of extracellular matrix in 
      progressive muscular dystrophy.
FAU - Yamazaki, M
AU  - Yamazaki M
AD  - Department of Neurology, Faculty of Medicine, University of Tokyo, Japan.
FAU - Minota, S
AU  - Minota S
FAU - Sakurai, H
AU  - Sakurai H
FAU - Miyazono, K
AU  - Miyazono K
FAU - Yamada, A
AU  - Yamada A
FAU - Kanazawa, I
AU  - Kanazawa I
FAU - Kawai, M
AU  - Kawai M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Carrier Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Latent TGF-beta Binding Proteins)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Carrier Proteins/metabolism
MH  - Extracellular Matrix/metabolism
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Latent TGF-beta Binding Proteins
MH  - Muscles/*metabolism/pathology
MH  - Muscular Dystrophies/*metabolism/pathology
MH  - Rabbits
MH  - Transforming Growth Factor beta/*metabolism
PMC - PMC1887141
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
PMCR- 1994/08/01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
PHST- 1994/08/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Pathol. 1994 Feb;144(2):221-6.