PMID- 8311947
OWN - NLM
STAT- MEDLINE
DCOM- 19940318
LR  - 20191023
IS  - 0958-0670 (Print)
IS  - 0958-0670 (Linking)
VI  - 78
IP  - 6
DP  - 1993 Nov
TI  - Correlation between spontaneous bursts of activity recorded from the dorsal roots 
      in an isolated hamster spinal cord preparation.
PG  - 811-24
AB  - At a temperature of 25-27 degrees C spontaneous antidromic activity has been 
      demonstrated in lumbar and thoracic dorsal roots of an isolated spinal cord 
      preparation taken from the golden hamster. A characteristic pattern of bursts of 
      action potentials has been identified, which develops within 1-2 h following 
      dissection and persists for more than 8 h. Simultaneous recordings made from 
      pairs of dorsal roots have revealed correlations between the patterns of 
      spontaneous activity in dorsal roots separated by up to sixteen segments 
      longitudinally and across the cord. The strongest correlations were found between 
      pairs of adjacent roots on the same side of the cord which produced a 
      cross-correlation histogram having a single peak with a mode close to 0 ms. As 
      the separation between the roots was increased the cross-correlation histogram 
      became bimodal, with peaks equidistant on either side of 0 ms. Activity recorded 
      in ipsilateral and contralateral pairs of roots supplying the same spinal segment 
      also produced bimodal cross-correlation histograms. Transverse sectioning of the 
      cord did not abolish spontaneous activity in any of the spinal roots examined, 
      although there was a progressive reduction in the frequency of the bursts of 
      spontaneous activity with shorter lengths of cord. These results suggest that 
      each spinal segment is capable of generating spontaneous activity, and that there 
      is a system by which adjacent segments are linked, allowing the activity to 
      spread up and down the cord from the point of origin. The networks associated 
      with the spread of dorsal root activity and primary afferent depolarization (PAD) 
      in the spinal cord are discussed.
FAU - Chen, Y
AU  - Chen Y
AD  - Department of Physiology and Pharmacology, School of Biomedical Sciences, 
      University of Southampton.
FAU - Bagust, J
AU  - Bagust J
FAU - Kerkut, G A
AU  - Kerkut GA
FAU - Tyler, A W
AU  - Tyler AW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Exp Physiol
JT  - Experimental physiology
JID - 9002940
SB  - IM
MH  - Action Potentials/physiology
MH  - Afferent Pathways/physiology
MH  - Animals
MH  - Cricetinae
MH  - Electrophysiology
MH  - In Vitro Techniques
MH  - Mesocricetus
MH  - Models, Neurological
MH  - Spinal Cord/anatomy & histology/*physiology
MH  - Spinal Nerve Roots/anatomy & histology/*physiology
MH  - Time Factors
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 10.1113/expphysiol.1993.sp003728 [doi]
PST - ppublish
SO  - Exp Physiol. 1993 Nov;78(6):811-24. doi: 10.1113/expphysiol.1993.sp003728.