PMID- 8313937
OWN - NLM
STAT- MEDLINE
DCOM- 19940323
LR  - 20131121
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 125
IP  - 2
DP  - 1994 Feb
TI  - A single intramesencephalic injection of brain-derived neurotrophic factor 
      induces persistent rotational asymmetry in rats.
PG  - 183-94
AB  - Brain-derived neurotrophic factor (BDNF) is expressed in dopaminergic neurons of 
      the substantia nigra pars compacta (SNpc) and the ventral tegmental area and 
      provides trophic support for these neurons in vitro. To study the effects of BDNF 
      on the nigrostrital dopaminergic system in vivo, we administered a single, 
      unilateral injection of BDNF into the medial SNpc of rats and evaluated 
      rotational behavior, striatal levels of dopamine and metabolites, and number of 
      dopaminergic neurons in the SNpc. We found that a single injection of 2 or 3 
      micrograms of BDNF, but not of vehicle, caused a persistent increase in the net 
      number of amphetamine-induced rotations/min contraversive to the site of 
      injection. The pattern of rotation is consistent with increased activity of the 
      nigrostriatal dopaminergic system on the side of injection. The 
      amphetamine-induced contraversive rotation could be blocked by administration of 
      the dopaminergic antagonist haloperidol. Apomorphine, a direct-acting 
      dopaminergic agonist, did not induce rotation. Levels of dopamine in the striatum 
      and number of dopaminergic neurons in the SNpc were similar in BDNF- and 
      vehicle-treated animals. The increase in contraversive rotations persisted for up 
      to 12 months after a single injection of BDNF.
FAU - Shults, C W
AU  - Shults CW
AD  - Neurology Service, VA Medical Center, San Diego, California.
FAU - Matthews, R T
AU  - Matthews RT
FAU - Altar, C A
AU  - Altar CA
FAU - Hill, L R
AU  - Hill LR
FAU - Langlais, P J
AU  - Langlais PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Amphetamines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Amphetamines/pharmacology
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor
MH  - Dopamine/metabolism
MH  - Female
MH  - Injections
MH  - Motor Activity/*drug effects
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Substantia Nigra/*metabolism
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - S0014-4886(84)71023-5 [pii]
AID - 10.1006/exnr.1994.1023 [doi]
PST - ppublish
SO  - Exp Neurol. 1994 Feb;125(2):183-94. doi: 10.1006/exnr.1994.1023.