PMID- 8314298
OWN - NLM
STAT- MEDLINE
DCOM- 19940322
LR  - 20221207
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 56
IP  - 2
DP  - 1994 Jan 15
TI  - The effect of ethnic differences on the pattern of HTLV-I-associated T-cell 
      leukemia/lymphoma (HATL) in the United States.
PG  - 177-81
AB  - Human T-cell lymphotropic virus Type I (HTLV-I) is the primary etiologic factor 
      for adult T-cell leukemia/lymphoma (ATL). Although HTLV-I is endemic in Japan and 
      the Caribbean islands, the reported clinical and epidemiologic features of ATL in 
      these 2 parts of the world are quite different. ATL has been diagnosed at a 
      younger age and is reported more frequently as the lymphomatous type rather than 
      the acute type with leukemia in the Caribbean basin as compared with the 
      presentation in Japan. In order to characterize ATL in the United States, a 
      registry has been established at the National Cancer Institute for the purpose of 
      recording all cases originally diagnosed in the United States. This registry was 
      utilized to examine the effect of ethnic differences on age of onset and clinical 
      features of ATL, using the same data base. Clinical and laboratory information 
      was obtained from 177 patients suspected of having ATL, who were treated at the 
      National Institutes of Health, or had biological samples sent for evaluation, or 
      were reported in the literature. Histopathologic review and virologic studies 
      were performed by standardized methods. Of 177 patients registered, 127 were 
      considered as having ATL, according to an algorithm combining clinical, 
      pathologic and laboratory features. Presenting features in the confirmed cases 
      consisted primarily of lymphadenopathy (76.6%), hypercalcemia (72.5%), leukemia 
      (82%), skin involvement (48.2%) and hepatomegaly (53.6%). Patients of Japanese 
      ancestry were generally older (median age 63, range 51 to 73 years) than patients 
      of African-American descent (median age 39, range 7 to 75 years) and presented 
      more often with leukemia (90 vs. 69%).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Levine, P H
AU  - Levine PH
AD  - National Cancer Institute, Bethesda, MD 20892.
FAU - Manns, A
AU  - Manns A
FAU - Jaffe, E S
AU  - Jaffe ES
FAU - Colclough, G
AU  - Colclough G
FAU - Cavallaro, A
AU  - Cavallaro A
FAU - Reddy, G
AU  - Reddy G
FAU - Blattner, W A
AU  - Blattner WA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Black or African American
MH  - Aged
MH  - Black People
MH  - Child
MH  - *Ethnicity
MH  - Female
MH  - Hispanic or Latino
MH  - Humans
MH  - Inuit
MH  - Japan/epidemiology/ethnology
MH  - Leukemia-Lymphoma, Adult T-Cell/epidemiology/*ethnology
MH  - Male
MH  - Middle Aged
MH  - United States/epidemiology
MH  - White People
EDAT- 1994/01/15 00:00
MHDA- 1994/01/15 00:01
CRDT- 1994/01/15 00:00
PHST- 1994/01/15 00:00 [pubmed]
PHST- 1994/01/15 00:01 [medline]
PHST- 1994/01/15 00:00 [entrez]
AID - 10.1002/ijc.2910560205 [doi]
PST - ppublish
SO  - Int J Cancer. 1994 Jan 15;56(2):177-81. doi: 10.1002/ijc.2910560205.