PMID- 8314570
OWN - NLM
STAT- MEDLINE
DCOM- 19930726
LR  - 20101118
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 16
IP  - 2
DP  - 1993 May
TI  - Physical and genetic maps for chromosome 10.
PG  - 320-4
AB  - A fluorescence in situ hybridization (FISH) physical map of 14 polymorphic loci 
      on chromosome 10 covers over 62% of the fractional length of chromosome 10. The 
      positions of three previously mapped loci are confirmed, nine more are refined, 
      and two new loci are cytogenetically mapped. The order of loci determined by FISH 
      agrees with that obtained by genetic linkage studies. When the distance estimates 
      for the physical map are compared to the distance estimates of our existing 
      linkage map, the sex average ratio of the fractional length (FL) per centimorgan 
      (cM) for this portion of chromosome 10 is 0.004 (or 0.4% FL/cM). However, the 
      average ratios for male- and female-specific genetic distances are quite 
      different, in agreement with an overall higher rate of recombination in females 
      (0.008 FL/cM and 0.003 FL/cM, respectively). Moreover, the ratio across the 
      centromere is larger for both the male (0.031 FL/cM) and the female (0.009 FL/cM) 
      than the ratio encompassing the q arm (0.006 FL/cM for males and 0.002 FL/cM for 
      females), suggesting that there is reduced recombination at the centromere in 
      both the male and the female maps when compared to the physical distance 
      generated from FISH on metaphase chromosomes.
FAU - Lichter, J B
AU  - Lichter JB
AD  - Yale University, Department of Genetics, New Haven, Connecticut 06510.
FAU - Difilippantonio, M J
AU  - Difilippantonio MJ
FAU - Pakstis, A J
AU  - Pakstis AJ
FAU - Goodfellow, P J
AU  - Goodfellow PJ
FAU - Ward, D C
AU  - Ward DC
FAU - Kidd, K K
AU  - Kidd KK
LA  - eng
GR  - 5-T15-LM07056-05/LM/NLM NIH HHS/United States
GR  - CA32066/CA/NCI NIH HHS/United States
GR  - HG00272/HG/NHGRI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Chromosome Mapping/*methods
MH  - *Chromosomes, Human, Pair 10/ultrastructure
MH  - Female
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Recombination, Genetic
MH  - Reference Standards
MH  - Sex Characteristics
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
AID - S0888-7543(83)71192-4 [pii]
AID - 10.1006/geno.1993.1192 [doi]
PST - ppublish
SO  - Genomics. 1993 May;16(2):320-4. doi: 10.1006/geno.1993.1192.