PMID- 8315827
OWN - NLM
STAT- MEDLINE
DCOM- 19930727
LR  - 20061115
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 34
IP  - 5
DP  - 1993 May
TI  - [Tumor suppressor genes and their role in abnormal production of leukocytes 
      (leukemogenesis)].
PG  - 572-7
AB  - The retinoblastoma susceptibility gene (RB) and p53 gene are now known to be the 
      prototypes for a class of tumor suppressor genes. Both genes act as a regulator 
      of cell cycle transition at G1/S in many types of cell lineages. 
      Underphosphorylated form of RB protein (Rd) acts as a growth suppressor by 
      blocking exit from G1 through a specific binding to E2F or promoter region of 
      certain growth-associated genes. Phosphorylation of Rb can be viewed as 
      inactivating Rb and allowing cell cycle progression to occur. Differentiation of 
      hematopoietic cell is accompanied with the loss of ability to phosphorylate Rb, 
      indicating that Rb plays an important role in hematopoietic cell growth and 
      differentiation. Abnormalities of RB gene may, therefore, predispose to the 
      development of hematologic malignancies. DNA rearrangement was reported to be 
      present in 1.5-12.1% of cases with primary leukemias, and the absence of RB 
      protein was also observed in 6.3-23.2%. The abnormalities of p53 gene were also 
      frequently observed in hematologic malignancies. DNA rearrangement of p53 was 
      observed in 20-30% of the cases with blastic crisis of CML. Point mutation at the 
      "hot spot" was reported in many types of leukemias, especially in cell lines 
      established from these cases.
FAU - Furukawa, Y
AU  - Furukawa Y
AD  - Division of Hemopoiesis, Jichi Medical School.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
SB  - IM
MH  - Base Sequence
MH  - Genes, Retinoblastoma/*physiology
MH  - Genes, p53/*physiology
MH  - Granulocytes/*physiology
MH  - Hematopoiesis/*physiology
MH  - Humans
MH  - Leukemia/genetics
MH  - Molecular Sequence Data
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
PST - ppublish
SO  - Rinsho Ketsueki. 1993 May;34(5):572-7.