PMID- 8319088
OWN - NLM
STAT- MEDLINE
DCOM- 19930803
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 610
IP  - 2
DP  - 1993 May 7
TI  - Nerve growth factor affects defense-related behaviors, but not lordosis, in 
      ovariectomized, estrogen-treated rats.
PG  - 256-66
AB  - Effects of NGF and anti-NGF on estrogen-sensitive behaviors were examined in 
      ovariectomized, estrogen-treated rats. Intracerebroventricular (i.c.v.) 
      administration of NGF resulted in a significant decrease in body weight. Daily 
      treatment with low levels of estradiol resulted in a steady increase in lordosis 
      behavior as reflected by average lordosis quotient and lordosis score. No effects 
      of NGF or anti-NGF on lordosis behavior were detected. Estrogen treatment also 
      resulted in a significant increase in the number of vocalizations elicited from 
      female controls by male contact during sex behavior. NGF-treatment enhanced this 
      effect, resulting in significantly more vocalizations elicited earlier in the 
      course of estrogen treatment than were elicited from non-NGF-treated controls. 
      These effects were blocked by progesterone. An increase in the number of 
      rejections elicited by male contact during sex behavior was also observed in 
      NGF-treated animals relative to controls. In addition, i.c.v. infusions of 
      anti-NGF prevented the estrogen-mediated increase in elicited vocalizations, 
      suggesting that NGF may have a physiological role in regulating this behavior. 
      These data implicate NGF in the regulation of specific defense-related behaviors 
      in estrogen-treated rats. Effects of NGF and anti-NGF on immunocytochemical 
      staining for p75NGFR-, and ChAT-like immunoreactivity were also analyzed and are 
      discussed.
FAU - Gibbs, R B
AU  - Gibbs RB
AD  - Rockefeller University, New York, NY 10021.
FAU - McCarthy, M M
AU  - McCarthy MM
FAU - Pfaff, D W
AU  - Pfaff DW
LA  - eng
GR  - NS28896/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Nerve Growth Factors)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
SB  - IM
MH  - Aggression/*drug effects
MH  - Animals
MH  - Brain/anatomy & histology/drug effects
MH  - Choline O-Acetyltransferase/immunology/metabolism
MH  - Estradiol/*pharmacology
MH  - Female
MH  - Immunohistochemistry
MH  - Injections, Intraventricular
MH  - Nerve Growth Factors/antagonists & inhibitors/immunology/*pharmacology
MH  - *Ovariectomy
MH  - *Posture
MH  - Progesterone/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sexual Behavior, Animal/*drug effects
MH  - Vocalization, Animal/drug effects
MH  - Weight Gain/drug effects
EDAT- 1993/05/07 00:00
MHDA- 1993/05/07 00:01
CRDT- 1993/05/07 00:00
PHST- 1993/05/07 00:00 [pubmed]
PHST- 1993/05/07 00:01 [medline]
PHST- 1993/05/07 00:00 [entrez]
AID - 0006-8993(93)91409-L [pii]
AID - 10.1016/0006-8993(93)91409-l [doi]
PST - ppublish
SO  - Brain Res. 1993 May 7;610(2):256-66. doi: 10.1016/0006-8993(93)91409-l.