PMID- 8319358
OWN - NLM
STAT- MEDLINE
DCOM- 19930805
LR  - 20190623
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 88
IP  - 1
DP  - 1993 Jul
TI  - Regional wall motion analysis predicts survival and functional outcome after 
      subendocardial resection in patients with prior anterior myocardial infarction.
PG  - 70-6
AB  - BACKGROUND: Subendocardial resection is an established surgical technique for the 
      treatment of ventricular tachycardia associated with prior myocardial infarction. 
      Preoperative factors predictive of survival and functional outcome after surgery 
      have not been completely characterized. We hypothesized that a quantitative 
      assessment of regional wall motion would be a sensitive predictor of both 
      survival and functional outcome after subendocardial resection. This was 
      retrospectively tested in a group of 80 patients with prior anterior myocardial 
      infarction who had undergone subendocardial resection for sustained ventricular 
      tachycardia at out institution. METHODS AND RESULTS: Centerline chord motion 
      analysis was used to derive a wall motion score from the preoperative contrast 
      right anterior oblique ventriculogram. Multivariate analysis revealed wall motion 
      score to be a significant independent predictor of both long-term survival (p < 
      0.01) and New York Heart Association (NYHA) functional class I or II status at 6 
      months (p < 0.01) and at 24 months (p < 0.001) after surgery. Patients with a 
      wall motion score of > 16%, compared with patients with a wall motion score of < 
      or = 16%, had a better 5-year actuarial survival (74% versus 45%, p = 0.02) and 
      were more likely to be NYHA class I or II at 6 months (87% versus 58%, p < 0.01) 
      and at 24 months (82% versus 34%, p < 0.0001) after subendocardial resection. 
      CONCLUSIONS: A wall motion score derived from centerline chord motion analysis is 
      a sensitive predictor of survival and functional outcome after subendocardial 
      resection. Patients with a wall motion score of > 16% have an excellent prognosis 
      after subendocardial resection. In contrast, patients with a wall motion score of 
      < or = 16% have a poorer outcome and should be considered candidates only if 
      other forms of therapy have failed or are unavailable.
FAU - Nath, S
AU  - Nath S
AD  - Department of Medicine, University of Virginia Health Sciences Center, 
      Charlottesville 22908.
FAU - Haines, D E
AU  - Haines DE
FAU - Kron, I L
AU  - Kron IL
FAU - Barber, M J
AU  - Barber MJ
FAU - DiMarco, J P
AU  - DiMarco JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
CIN - Circulation. 1994 Apr;89(4):1906. PMID: 8149559
MH  - Cardiac Pacing, Artificial
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardial Contraction/*physiology
MH  - Myocardial Infarction/*mortality/physiopathology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Tachycardia, Ventricular/mortality/*surgery
MH  - Ventricular Function, Left/*physiology
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 10.1161/01.cir.88.1.70 [doi]
PST - ppublish
SO  - Circulation. 1993 Jul;88(1):70-6. doi: 10.1161/01.cir.88.1.70.