PMID- 8319397
OWN - NLM
STAT- MEDLINE
DCOM- 19930803
LR  - 20190721
IS  - 0363-9762 (Print)
IS  - 0363-9762 (Linking)
VI  - 18
IP  - 6
DP  - 1993 Jun
TI  - Captopril renoscintigraphy with Tc-99m DTPA in patients with suspected 
      renovascular hypertension. Prospective and retrospective evaluation.
PG  - 463-71
AB  - Sensitivity and specificity of captopril renoscintigraphy (CRS) with Tc-99m DTPA 
      has been analyzed in 41 cases, 16 with renovascular hypertension (RVH) and 25 
      with non-RVH. The sensitivity and specificity of the baseline study were 63% 
      (10/16) and 63% (12/19), respectively, based on the split renal function study in 
      which the lower limit of normal was assumed to be 42% of the total renal uptake. 
      Captopril renoscintigraphy yielded 67% (12/18) sensitivity and 76% (19/25) 
      specificity. The low specificity of CRS was due to the application of a 
      prospective criterion of the captopril-induced reduction rate (CRR) of less than 
      -20%, which was calculated from the renal uptake before and after captopril. When 
      criteria of CRR less than -25% were used, the specificity of CRS was improved to 
      96%, but the sensitivity declined to 61%. Changes in the configuration of the 
      renogram induced by captopril also had high specificity but low sensitivity. 
      Renovascular hypertension was most likely when criteria for both CRR and the 
      renogram were fulfilled. These criteria often were diagnostic in patients with 
      bilateral renal artery stenosis that showed variable scintigraphic responses to 
      captopril challenge. Captopril renoscintigraphy is a very specific means to 
      evaluate RVH, but may have limitations in certain clinical situations such as 
      poorly preserved function of the affected kidney, prior long-term administration 
      of captopril, prior surgical manipulation of stenotic renal artery, and chronic 
      renal parenchymal damage.
FAU - Itoh, K
AU  - Itoh K
AD  - Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, 
      Japan.
FAU - Tsukamoto, E
AU  - Tsukamoto E
FAU - Nagao, K
AU  - Nagao K
FAU - Nakada, K
AU  - Nakada K
FAU - Kanegae, K
AU  - Kanegae K
FAU - Furudate, M
AU  - Furudate M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Nucl Med
JT  - Clinical nuclear medicine
JID - 7611109
RN  - 9G64RSX1XD (Captopril)
RN  - VW78417PU1 (Technetium Tc 99m Pentetate)
SB  - IM
MH  - Adult
MH  - *Captopril
MH  - False Negative Reactions
MH  - False Positive Reactions
MH  - Female
MH  - Glomerular Filtration Rate/drug effects
MH  - Humans
MH  - Hypertension, Renovascular/*diagnostic imaging/epidemiology
MH  - Male
MH  - Prospective Studies
MH  - Radioisotope Renography/*methods
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - *Technetium Tc 99m Pentetate
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 10.1097/00003072-199306000-00001 [doi]
PST - ppublish
SO  - Clin Nucl Med. 1993 Jun;18(6):463-71. doi: 10.1097/00003072-199306000-00001.