PMID- 8325081
OWN - NLM
STAT- MEDLINE
DCOM- 19930810
LR  - 20190514
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 104
IP  - 1
DP  - 1993 Jul
TI  - The relationship between HLA-A, B, DQ, and DR antigens and asbestos-induced lung 
      disease.
PG  - 26-31
AB  - To evaluate the relationship between human leukocyte antigen (HLA) and both 
      asbestos-induced pulmonary fibrosis and pleural fibrosis, we obtained HLA-A, B, 
      C, DQ, and DR phenotypes in 42 long-term asbestos-exposed workers. Among these 
      exposed workers, 15 had asbestosis (ILO > or = 1/0) on the chest radiograph and 
      18 had asbestos-induced pleural fibrosis. We found that there was an increased 
      percentage of HLA-A29, HLA-B44, and HLA-Bw4 in the subjects with asbestosis. In 
      addition, we observed a marginally positive relationship between HLA-A29 and the 
      severity of pulmonary fibrosis. Similarly, there was a higher prevalence of 
      HLA-DRw53 and DQ2 in the subjects with asbestos-induced pleural fibrosis. The 
      presence of HLA-DQ2 was significantly related to the extent and type of 
      asbestos-induced pleural fibrosis while HLA-DRw53 was not consistently related to 
      the type or extent of pleural disease. Importantly, we observed that HLA-A29, 
      HLA-B44, HLA-Bw4, HLA-DRw53, and HLA-DQ2 do not have a significantly shorter 
      duration or latency of asbestos exposure. Moreover, none of the HLA haplotypes 
      (A29, B44, Bw4, DRw53, and DQ2) that we found to be associated with radiographic 
      manifestations of asbestos-induced lung disease were associated with the 
      physiologic abnormalities that have been traditionally associated with 
      asbestos-induced lung disease. The only exception was an isolated decrease in the 
      residual volume associated with the presence of HLA-A29. These results suggest 
      that the HLA-A29 phenotype may be associated with the development of asbestosis 
      and the HLA-DQ2 phenotype may be associated with the development of 
      asbestos-induced pleural fibrosis. However, these associations are not 
      particularly strong, physiologic correlation is lacking, and previous studies do 
      not support our findings.
FAU - Shih, J F
AU  - Shih JF
AD  - Department of Internal Medicine, Department of Veterans Affairs, Iowa City.
FAU - Hunninghake, G W
AU  - Hunninghake GW
FAU - Goeken, N E
AU  - Goeken NE
FAU - Galvin, J R
AU  - Galvin JR
FAU - Merchant, J A
AU  - Merchant JA
FAU - Schwartz, D A
AU  - Schwartz DA
LA  - eng
GR  - ES00203/ES/NIEHS NIH HHS/United States
GR  - OH00093/OH/NIOSH CDC HHS/United States
GR  - SCOR HL-37121/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A29 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B44 Antigen)
RN  - 0 (HLA-Bw4 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR53)
RN  - 0 (HLA-DRB4 Chains)
SB  - IM
MH  - Asbestosis/*immunology
MH  - Fibrosis
MH  - HLA-A Antigens/*analysis
MH  - HLA-B Antigens/*analysis
MH  - HLA-B44 Antigen
MH  - HLA-DQ Antigens/*analysis
MH  - HLA-DR Antigens/*analysis
MH  - HLA-DRB4 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pleural Diseases/*immunology
MH  - Pulmonary Fibrosis/*immunology
MH  - Respiratory Function Tests
MH  - Smoking
MH  - Time Factors
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - S0012-3692(16)47467-2 [pii]
AID - 10.1378/chest.104.1.26 [doi]
PST - ppublish
SO  - Chest. 1993 Jul;104(1):26-31. doi: 10.1378/chest.104.1.26.