PMID- 8325118
OWN - NLM
STAT- MEDLINE
DCOM- 19930810
LR  - 20190514
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 104
IP  - 1
DP  - 1993 Jul
TI  - Acute rise in serum immunoglobulin E concentration in pulmonary thromboembolism.
PG  - 61-4
AB  - Events mediated by immunoglobulin E (IgE) may be related to platelet activation 
      and aggregation, and there may be an association between IgE and pulmonary 
      thromboembolism (PTE). Fourteen patients with PTE were studied with regard to 
      serum concentrations of IgE, IgA, IgG, IgM, fibrinogen, and D-dimer and with 
      regard to blood neutrophil, lymphocyte, platelet, and eosinophil counts during 
      acute and recovery phases. The serum IgE concentration increased during the acute 
      phase to 402 +/- 310 IU/ml and decreased afterwards in all patients. The increase 
      in serum IgE concentration lagged a few days behind that of the serum D-dimer 
      concentration, indicating later IgE production than thrombus formation and lysis. 
      Infarction and pleural fluid accumulation developed in patients with a high 
      initial serum IgE concentration. These results indicated a relationship between 
      serum IgE concentration and the pathophysiology of PTE. Serum IgE may be an 
      indicator of the severity of PTE and provide insight into its pathogenesis, 
      thereby facilitating the diagnosis of PTE.
FAU - Takekawa, H
AU  - Takekawa H
AD  - First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, 
      Japan.
FAU - Miyamoto, K
AU  - Miyamoto K
FAU - Yamaguchi, E
AU  - Yamaguchi E
FAU - Munakata, M
AU  - Munakata M
FAU - Kawakami, Y
AU  - Kawakami Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (fibrin fragment D)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Eosinophils/pathology
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products/analysis
MH  - Fibrinogen/analysis
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Leukocyte Count
MH  - Lymphocytes/pathology
MH  - Male
MH  - Middle Aged
MH  - Neutrophils/pathology
MH  - Platelet Count
MH  - Pleural Effusion/blood/physiopathology
MH  - Pulmonary Embolism/*blood/drug therapy/immunology/physiopathology
MH  - Thrombolytic Therapy
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - S0012-3692(16)47473-8 [pii]
AID - 10.1378/chest.104.1.61 [doi]
PST - ppublish
SO  - Chest. 1993 Jul;104(1):61-4. doi: 10.1378/chest.104.1.61.