PMID- 8328368
OWN - NLM
STAT- MEDLINE
DCOM- 19930809
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 71
IP  - 17
DP  - 1993 Jun 24
TI  - Acute and long-term efficacy of perindopril in severe chronic congestive heart 
      failure.
PG  - 48E-56E
AB  - To assess the short- and long-term hemodynamic efficacy of perindopril, 15 
      patients (12 men and 3 women) diagnosed with congestive heart failure were 
      treated with oral perindopril (4 mg daily) for 3 months in association with 
      digitalis and diuretic maintenance therapy. Patients were in New York Heart 
      Association (NYHA) functional classes III and IV. Underlying cardiopathy was 
      ischemic (6 patients), hypertensive (5 patients), valvular (2 patients), and 
      dilated cardiomyopathy (2 patients). Hemodynamics, angiotensin-converting enzyme 
      (ACE) activity, and perindoprilat (the active metabolite of perindopril) blood 
      titration were measured at 2 periods. Acute assessment was performed over 2 
      titration days on oral perindopril 2 mg (day 1) and 4 mg (day 2); measurements 
      were performed at rest and at 0, 1, 4, 6, 8, 12, and 24 hours. Chronic assessment 
      was performed after 3 months of treatment with oral perindopril, 4 mg daily. 
      During the study, 1 patient withdrew due to low systolic blood pressure (< 100 mm 
      Hg) and 3 severely impaired patients died due to a worsening of heart failure 
      during the study. Among the 11 remaining patients, 6 were symptomatically 
      improved. On 4 mg perindopril administration, hemodynamic improvement was similar 
      for peak values at both day 2 and at 3 months. At day 2, compared with baseline, 
      cardiac index increased by 21% (p < 0.05) and pulmonary capillary wedge pressure 
      (PCWP) and mean arterial pressure (MAP) decreased by 54% and by 21%, respectively 
      (p < 0.01). Similarly, at 3 months, cardiac index increased by 37% (p < 0.001) 
      and PCWP and MAP decreased by 41% and 19%, respectively (p < 0.01).(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Flammang, D
AU  - Flammang D
AD  - Department of Cardiology, Angouleme General Hospital, Saint Michel, France.
FAU - Waynberger, M
AU  - Waynberger M
FAU - Chassing, A
AU  - Chassing A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Indoles)
RN  - Y5GMK36KGY (Perindopril)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiotensin-Converting Enzyme 
      Inhibitors/pharmacokinetics/pharmacology/*therapeutic use
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/*drug therapy/physiopathology
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Indoles/pharmacokinetics/pharmacology/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Perindopril
EDAT- 1993/06/24 00:00
MHDA- 1993/06/24 00:01
CRDT- 1993/06/24 00:00
PHST- 1993/06/24 00:00 [pubmed]
PHST- 1993/06/24 00:01 [medline]
PHST- 1993/06/24 00:00 [entrez]
AID - 0002-9149(93)90953-A [pii]
AID - 10.1016/0002-9149(93)90953-a [doi]
PST - ppublish
SO  - Am J Cardiol. 1993 Jun 24;71(17):48E-56E. doi: 10.1016/0002-9149(93)90953-a.