PMID- 8329351
OWN - NLM
STAT- MEDLINE
DCOM- 19930819
LR  - 20190719
IS  - 0007-1145 (Print)
IS  - 0007-1145 (Linking)
VI  - 69
IP  - 3
DP  - 1993 May
TI  - The effect of Escherichia coli heat-stable (STA) enterotoxin on in vitro uptake 
      of amino acids by small intestine of sucking rats during fluid accumulation.
PG  - 757-66
AB  - In vitro uptake of 14C-labelled amino acids by segments of small intestine was 
      determined in sucking (2-4-d-old) Wistar rats. Intragastric injections of 
      heat-stable (ST) toxin of enterotoxigenic Escherichia coli (ETEC) were given to 
      produce fluid accumulation, defined as a gut weight: carcass weight value of > 
      0.085. Continued active uptake of the prototypic amino acids, leucine (by active 
      transport system 1 for monoamino monocarboxylic (neutral) amino acids), lysine 
      (by active transport system 2 for dibasic amino acids), and proline (by active 
      transport system 3 for N-substituted amino acids), persisted during the active 
      fluid accumulation response to ETEC ST toxin. The mean Kt and mean Vmax of the 
      amino acid transport systems were similar in control (non-injected) and ST 
      toxin-injected rats. The present study provides a scientific basis for the use of 
      amino acids in oral rehydration solutions utilizing amino acid transport systems 
      which are linked to absorption of Na (and water) so that reduction in diarrhoeal 
      stools can be achieved, and emphasizes the importance of maintaining feeding 
      during acute diarrhoea to prevent development of malnutrition.
FAU - Tin-Aung
AU  - Tin-Aung
FAU - Khin-Maung-U
AU  - Khin-Maung-U
FAU - Wai-Wai-Than
AU  - Wai-Wai-Than
FAU - Thida-Aung
AU  - Thida-Aung
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Amino Acids)
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (heat stable toxin (E coli))
SB  - IM
MH  - Amino Acids/*metabolism
MH  - Animals
MH  - Animals, Suckling/*metabolism
MH  - Bacterial Toxins/*pharmacology
MH  - Culture Techniques
MH  - Diarrhea/*metabolism
MH  - Disease Models, Animal
MH  - Enterotoxins/*pharmacology
MH  - Escherichia coli Proteins
MH  - Intestinal Absorption/*drug effects
MH  - Intestine, Small/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
MH  - Water-Electrolyte Balance/*drug effects
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
AID - 10.1079/bjn19930076 [doi]
PST - ppublish
SO  - Br J Nutr. 1993 May;69(3):757-66. doi: 10.1079/bjn19930076.