PMID- 8330539
OWN - NLM
STAT- MEDLINE
DCOM- 19930817
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 117
IP  - 2
DP  - 1993 Feb
TI  - Sex determination in Drosophila: sis-b, a major numerator element of the X:A 
      ratio in the soma, does not contribute to the X:A ratio in the germ line.
PG  - 763-7
AB  - In soma and germ cells of Drosophila, the X:A ratio builds a primary signal for 
      sex determination, and in both tissues Sex-lethal (Sxl) function is required for 
      cells to enter the female pathway. In somatic cells of XX animals, the products 
      of X-chromosomal elements of the X:A ratio activate Sxl. Here I show that 
      sisterless-b (sis-b), which is the X-chromosomal element of the somatic X:A ratio 
      that has best been analysed, is not required for oogenesis. I also present 
      evidence that Sxl function might not be sufficient to direct germ cells into the 
      female pathway. These results show that the elements forming the X:A ratio in the 
      germ line are different from the elements forming the X:A ratio in the soma and 
      they suggest that, in the germ line, Sxl might not be regulated by the X:A ratio.
FAU - Steinmann-Zwicky, M
AU  - Steinmann-Zwicky M
AD  - Institute of Zoology, University Zurich-Irchel, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
SB  - IM
GS  - Sx1
GS  - sis-b
MH  - Animals
MH  - Drosophila/embryology/*genetics
MH  - Female
MH  - Genes, Insect/*genetics
MH  - Genotype
MH  - Germ Cells/*physiology
MH  - Male
MH  - Oogenesis/genetics
MH  - *Sex Chromosomes
MH  - *Sex Determination Analysis
MH  - Spermatogenesis/genetics
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1242/dev.117.2.763 [doi]
PST - ppublish
SO  - Development. 1993 Feb;117(2):763-7. doi: 10.1242/dev.117.2.763.