PMID- 8331160
OWN - NLM
STAT- MEDLINE
DCOM- 19930816
LR  - 20190825
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 45
IP  - 1-2
DP  - 1993 Jun
TI  - Tumor necrosis factor-alpha in immune-mediated demyelination and Wallerian 
      degeneration of the rat peripheral nervous system.
PG  - 175-82
AB  - This study reports on the immunocytochemical localization of tumor necrosis 
      factor-alpha (TNF alpha) in immune-mediated demyelination and Wallerian 
      degeneration of the rat peripheral nervous system (PNS) using teased nerve fiber 
      preparations. In experimental autoimmune neuritis induced by active immunization 
      (EAN) or by adoptive transfer of autoreactive T cells (AT-EAN), macrophages 
      passing blood vessels as well as macrophages adherent to nerve fibers were TNF 
      alpha-positive. Large post-phagocytic macrophages at later stages of 
      demyelination were TNF alpha-negative. Intraperitoneal application of an anti-TNF 
      alpha antibody to EAN rats significantly reduced the degree of inflammatory 
      demyelination, suggesting a pathogenic role for TNF alpha. After nerve 
      transection only macrophages located within degenerating nerve fibers were TNF 
      alpha-positive, while those entering and leaving nerves were negative. TNF alpha 
      produced by macrophages seems to be involved in immune-mediated demyelination and 
      non-immune myelin degradation after axotomy. While interferon-gamma (IFN gamma) 
      is present in EAN nerves and may act as a local stimulus for TNF expression, the 
      nature of this signal in Wallerian degeneration in the absence of IFN gamma is 
      unknown.
FAU - Stoll, G
AU  - Stoll G
AD  - Department of Neurology, Heinrich-Heine-Universitat, Dusseldorf, Germany.
FAU - Jung, S
AU  - Jung S
FAU - Jander, S
AU  - Jander S
FAU - van der Meide, P
AU  - van der Meide P
FAU - Hartung, H P
AU  - Hartung HP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antibodies)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology
MH  - Demyelinating Diseases/*immunology/*metabolism
MH  - Denervation
MH  - Female
MH  - Immunization
MH  - Immunohistochemistry
MH  - Peripheral Nerves/*metabolism/pathology
MH  - Rats
MH  - Rats, Inbred Lew
MH  - T-Lymphocytes/immunology/transplantation
MH  - Tissue Distribution
MH  - Tumor Necrosis Factor-alpha/immunology/*metabolism
MH  - *Wallerian Degeneration
EDAT- 1993/06/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 0165-5728(93)90178-2 [pii]
AID - 10.1016/0165-5728(93)90178-2 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1993 Jun;45(1-2):175-82. doi: 10.1016/0165-5728(93)90178-2.