PMID- 8335978
OWN - NLM
STAT- MEDLINE
DCOM- 19930824
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 168
IP  - 2
DP  - 1993 Aug
TI  - The influence of thalidomide on the clinical and immunologic manifestation of 
      erythema nodosum leprosum.
PG  - 408-14
AB  - Immunologic and clinical manifestations of erythema nodosum leprosum (ENL) and 
      their response to thalidomide therapy were evaluated. Circulating tumor necrosis 
      factor-alpha (TNF alpha) levels were assayed in serum obtained from lepromatous 
      leprosy patients at diagnosis, during multidrug therapy, at the onset of ENL 
      episodes, and during treatment with thalidomide. Patients with systemic ENL 
      demonstrated the highest serum TNF alpha levels, which decreased significantly 
      during thalidomide treatment. Serum TNF alpha in nonreactional patients was 
      associated with mild flu-like symptoms and local inflammatory lesions. Serum 
      interferon-gamma (IFN-gamma) was also elevated in patients with high TNF alpha 
      levels. Thalidomide therapy reduced not only serum TNF alpha levels and the 
      clinical symptoms but also the dermal infiltration of polymorphonuclear 
      leukocytes and T cells. The expression of intercellular adhesion molecule 1 and 
      major histocompatibility complex class II antigens on the epidermal keratinocytes 
      was also down-regulated. These results indicate that the thalidomide-induced 
      alleviation of clinical symptoms of ENL was associated with a reduction of TNF 
      alpha levels.
FAU - Sampaio, E P
AU  - Sampaio EP
AD  - Leprosy Unit, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
FAU - Kaplan, G
AU  - Kaplan G
FAU - Miranda, A
AU  - Miranda A
FAU - Nery, J A
AU  - Nery JA
FAU - Miguel, C P
AU  - Miguel CP
FAU - Viana, S M
AU  - Viana SM
FAU - Sarno, E N
AU  - Sarno EN
LA  - eng
GR  - AI-22616/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4Z8R6ORS6L (Thalidomide)
SB  - IM
MH  - Adult
MH  - Erythema Nodosum/*drug therapy/pathology
MH  - Female
MH  - Humans
MH  - Leprosy, Lepromatous/*drug therapy/pathology
MH  - Male
MH  - Middle Aged
MH  - Thalidomide/*therapeutic use
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - 10.1093/infdis/168.2.408 [doi]
PST - ppublish
SO  - J Infect Dis. 1993 Aug;168(2):408-14. doi: 10.1093/infdis/168.2.408.